Brecx M, Macdonald L L, Legary K, Cheang M, Forgay M G
Faculty of Dentistry, University of Manitoba, Winnipeg, Canada.
J Dent Res. 1993 Aug;72(8):1194-7. doi: 10.1177/00220345930720080601.
The aim of the present study was to compare the effect on plaque growth and gingival response of Meridol, an amine/stannous fluoride solution, during a three-month investigation, with those of a placebo preparation as a negative control and a chlorhexidine solution as a positive control, in a double-blind study. After having their teeth professionally cleaned, 36 volunteers continued their usual oral hygiene for a period of two weeks. Their teeth were then polished again (month 0) after which they rinsed twice daily (morning and evening) with one of the three mouthrinses in addition to their habitual toothcleaning. After three months of rinsing, plaque indices remained lowest in the chlorhexidine group, although the subjects using Meridol had indices significantly lower than those of individuals rinsing with the placebo solution. The gingival index scores in the Meridol group were higher than in the chlorhexidine group and lower than in the placebo group. The plaque vitality scores showed a bactericidal effect in vivo with chlorhexidine and Meridol during the entire experiment. The use of Meridol resulted in more toothstaining than with the placebo, but significantly less than with chlorhexidine. This study demonstrated that Meridol reduced plaque accumulation, retarded gingivitis development, possessed a definite bactericidal action, and produced only slight toothstaining.
本研究的目的是在一项双盲研究中，比较在为期三个月的调查期间，胺/氟化亚锡溶液Meridol对菌斑生长和牙龈反应的影响，与作为阴性对照的安慰剂制剂和作为阳性对照的洗必泰溶液的影响。36名志愿者在接受专业牙齿清洁后，维持两周的常规口腔卫生。然后在第0个月再次对他们的牙齿进行抛光，之后除了日常刷牙外，他们每天早晚用三种漱口水之一漱口两次。漱口三个月后，洗必泰组的菌斑指数仍然最低，不过使用Meridol的受试者的指数明显低于用安慰剂溶液漱口的个体。Meridol组的牙龈指数得分高于洗必泰组且低于安慰剂组。在整个实验过程中，菌斑活力得分显示洗必泰和Meridol在体内具有杀菌作用。使用Meridol比使用安慰剂导致更多的牙齿染色，但明显少于使用洗必泰。这项研究表明，Meridol减少了菌斑积聚，延缓了牙龈炎的发展，具有明确的杀菌作用，并且只产生轻微的牙齿染色。
