Sjögren U, Norberg B, Rydgren L
Acta Med Scand. 1977;201(4):381-6. doi: 10.1111/j.0954-6820.1977.tb15716.x.
The incidence of amoeboid movement configuration (AMC), a cell shape suggestive of cell locomotion at the moment of fixation, has been studied in the tumour cells of bone marrow smears from leukaemia patients at the time of diagnosis. The groups of patients with CML (n = 8), ALL (n = 5) and CLL (n = 9) were small, and the incidences of AMC were close to those found in the corresponding cell lines from healthy probands. In 39 patients with AML, the incidence of AMC was higher than in the other cell lines investigated. A positive skew distribution of AMC values and a positive significant correlation between incidence of AMC were found at the time of diagnosis and subsequent survival of the patients with AML, in spite of differences in treatment. It is suggested that this positive correlation may be due to an immune reaction of the patients against their tumour cells.
在白血病患者诊断时，对骨髓涂片肿瘤细胞中阿米巴样运动形态（AMC）的发生率进行了研究，AMC是一种在固定时提示细胞运动的细胞形态。慢性粒细胞白血病（CML，n = 8）、急性淋巴细胞白血病（ALL，n = 5）和慢性淋巴细胞白血病（CLL，n = 9）患者组规模较小，AMC发生率与健康对照相应细胞系中的发生率相近。在39例急性髓细胞白血病（AML）患者中，AMC发生率高于其他所研究的细胞系。尽管治疗存在差异，但在AML患者诊断时发现AMC值呈正偏态分布，且AMC发生率与患者随后的生存率之间存在显著正相关。提示这种正相关可能是由于患者对其肿瘤细胞的免疫反应所致。
