近红外激光激活“纳米炸弹”突破 miRNA 递送障碍
A Near-Infrared Laser-Activated "Nanobomb" for Breaking the Barriers to MicroRNA Delivery.
机构信息
Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA.
Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
出版信息
Adv Mater. 2016 Jan 13;28(2):347-55. doi: 10.1002/adma.201504263. Epub 2015 Nov 16.
PMID:26567892
Abstract
A near-infrared laser-activated "nanobomb" is synthesized using lipid and multiple polymers to break the extra-cellular and intracellular barriers to cytosolic delivery of microRNAs. The nanobomb can be used to effectively destroy tumors and cancer stem-like cells in vitro and in vivo with minimal side effects.
摘要
近红外激光激活的“纳米炸弹”是使用脂质和多种聚合物合成的，用于突破细胞外和细胞内的屏障，实现 microRNAs 的细胞质递送。该纳米炸弹可有效破坏体外和体内的肿瘤和癌症干细胞样细胞，副作用极小。
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