Hagymási Krisztina, Egresi Anna, Lengyel Gabriella
II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Szentkirályi u. 46., 1088.
Orv Hetil. 2015 Nov 22;156(47):1884-7. doi: 10.1556/650.2015.30302.
In the past years great importance has been attributed to antioxidant therapy in the prevention and treatment of disorders developed in connection with oxidative stress. After initial success, undesirable effects, toxicities, and prooxidant effects of antioxidants were reported [CARET, ATBC study]. In addition, metaanalyses failed to confirm the role of antioxidant supplementation in the primary and secondary prevention. The authors review the prooxidant effects of antioxidants, and their role in cell signalling and cell process modulation. Finally, the authors summarize possible explanations why combined use of antiooxidants is more favourable.
在过去几年中，抗氧化疗法在预防和治疗与氧化应激相关的疾病方面具有重要意义。在取得初步成功后，有报道称抗氧化剂存在不良影响、毒性和促氧化作用[CARET，ATBC研究]。此外，荟萃分析未能证实补充抗氧化剂在一级和二级预防中的作用。作者回顾了抗氧化剂的促氧化作用及其在细胞信号传导和细胞过程调节中的作用。最后，作者总结了联合使用抗氧化剂更有益的可能原因。
