Department of Clinical Chemistry and Biochemistry, Medical University of Łódź, Łódź, Poland.
Int J Occup Med Environ Health. 2012 Jun;25(2):105-21. doi: 10.2478/S13382-012-0022-x. Epub 2012 Apr 19.
High doses of synthetic antioxidative vitamins: A, E, C and β-carotene are often used on long-term basis in numerous preventive and therapeutic medical applications. Instead of expected health effects, the use of those vitamins may however lead to cases of hypervitaminosis and even to intoxication. The article points out main principles of safety which are to be observed during supplementation with antioxidative vitamins. Toxic effects resulting from erroneous administration of high doses of those substances on organs and systems of the organism are also discussed. Attention is drawn to interactions of antioxidative vitamins with concomitantly used drugs, as well as intensification of adverse effects caused by various exogenous chemical factors. Moreover, the article presents the evaluation of supplementation with these vitamins, which was performed in large studies.
高剂量的合成抗氧化维生素，如 A、E、C 和β-胡萝卜素，经常被用于许多预防和治疗性的医学应用中，且使用时间通常较长。然而，与预期的健康效果相反，这些维生素的使用可能导致维生素过多症，甚至中毒。本文指出了在补充抗氧化维生素时应遵守的主要安全原则。还讨论了由于错误地给机体器官和系统施用高剂量这些物质而导致的毒性作用。此外，还提请注意抗氧化维生素与同时使用的药物之间的相互作用，以及各种外源化学因素引起的不良反应的加剧。此外，本文还对这些维生素的补充进行了评估，这些评估是在大型研究中进行的。
