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Prognostic and theranostic impact of molecular subtypes and immune classifications in renal cell cancer (RCC) and colorectal cancer (CRC).分子亚型和免疫分类在肾细胞癌（RCC）和结直肠癌（CRC）中的预后及诊疗影响
Oncoimmunology. 2015 Aug 7;4(12):e1049804. doi: 10.1080/2162402X.2015.1049804. eCollection 2015 Dec.
2
The consensus molecular subtypes of colorectal cancer.结直肠癌的共识分子亚型
Nat Med. 2015 Nov;21(11):1350-6. doi: 10.1038/nm.3967. Epub 2015 Oct 12.
3
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.错配修复缺陷肿瘤中的程序性死亡受体-1阻断
N Engl J Med. 2015 Jun 25;372(26):2509-20. doi: 10.1056/NEJMoa1500596. Epub 2015 May 30.
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Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.癌症免疫学。突变图谱决定非小细胞肺癌对程序性死亡受体1（PD-1）阻断治疗的敏感性。
Science. 2015 Apr 3;348(6230):124-8. doi: 10.1126/science.aaa1348. Epub 2015 Mar 12.
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Molecular subtypes of clear cell renal cell carcinoma are associated with sunitinib response in the metastatic setting.透明细胞肾细胞癌的分子亚型与转移性环境中舒尼替尼的反应相关。
Clin Cancer Res. 2015 Mar 15;21(6):1329-39. doi: 10.1158/1078-0432.CCR-14-1128. Epub 2015 Jan 12.
6
Characteristics and clinical impacts of the immune environments in colorectal and renal cell carcinoma lung metastases: influence of tumor origin.结直肠癌和肾细胞癌肺转移的免疫环境特征和临床影响：肿瘤起源的影响。
Clin Cancer Res. 2013 Aug 1;19(15):4079-91. doi: 10.1158/1078-0432.CCR-12-3847. Epub 2013 Jun 19.
7
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.抗 PD-L1 抗体在晚期癌症患者中的安全性和活性。
N Engl J Med. 2012 Jun 28;366(26):2455-65. doi: 10.1056/NEJMoa1200694. Epub 2012 Jun 2.
8
The immune contexture in human tumours: impact on clinical outcome.人类肿瘤中的免疫结构：对临床结果的影响。
Nat Rev Cancer. 2012 Mar 15;12(4):298-306. doi: 10.1038/nrc3245.
9
Cancer-related inflammation.癌症相关炎症
Nature. 2008 Jul 24;454(7203):436-44. doi: 10.1038/nature07205.
10
Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs.在缺乏次级淋巴器官的情况下免疫记忆的持久性和反应性。
Immunity. 2006 Oct;25(4):643-54. doi: 10.1016/j.immuni.2006.08.022.

将肿瘤微环境与癌症分子分类相结合。

Integrating tumor microenvironment with cancer molecular classifications.

作者信息

Becht Etienne, de Reyniès Aurélien, Fridman Wolf H

机构信息

INSERM UMR_S 1138, Cancer, Immune Control and Escape, Cordeliers Research Centre, Paris, France.

Université Paris Descartes, Paris, France.

出版信息

Genome Med. 2015 Nov 14;7(1):115. doi: 10.1186/s13073-015-0241-4.

DOI:10.1186/s13073-015-0241-4
PMID:26568192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4644274/
Abstract

The composition of the tumor microenvironment is associated with a patient's prognosis and can be therapeutically targeted. A link between the cellular composition and genomic features of the tumor and its response to immunotherapy is beginning to emerge. Analyzing the microenvironment of tumor molecular subgroups can be a useful approach to tailor immunotherapies.

摘要

肿瘤微环境的组成与患者的预后相关，并且可以成为治疗靶点。肿瘤的细胞组成、基因组特征及其对免疫治疗的反应之间的联系正开始显现。分析肿瘤分子亚群的微环境可能是定制免疫治疗的一种有用方法。