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本文引用的文献

1
Changing Incidence of Serum 25-Hydroxyvitamin D Values Above 50 ng/mL: A 10-Year Population-Based Study.血清25-羟基维生素D水平高于50 ng/mL的发病率变化:一项基于人群的10年研究。
Mayo Clin Proc. 2015 May;90(5):577-86. doi: 10.1016/j.mayocp.2015.02.012.
2
Vitamin D Is Not as Toxic as Was Once Thought: A Historical and an Up-to-Date Perspective.维生素D并非如曾经认为的那样具有毒性:历史与最新观点
Mayo Clin Proc. 2015 May;90(5):561-4. doi: 10.1016/j.mayocp.2015.03.015.
3
Vitamin D: An overview of vitamin D status and intake in Europe.维生素D:欧洲维生素D状况与摄入量概述
Nutr Bull. 2014 Dec;39(4):322-350. doi: 10.1111/nbu.12108.
4
Cost-effectiveness of vitamin D and calcium supplementation in the treatment of elderly women and men with osteoporosis.维生素D和钙补充剂治疗老年骨质疏松症女性和男性的成本效益
Eur J Public Health. 2015 Feb;25(1):20-5. doi: 10.1093/eurpub/cku119. Epub 2014 Aug 5.
5
Expected lifetime numbers and costs of fractures in postmenopausal women with and without osteoporosis in Germany: a discrete event simulation model.德国有和没有骨质疏松症的绝经后女性骨折的预期终生数量和成本:一个离散事件模拟模型
BMC Health Serv Res. 2014 Jun 30;14:284. doi: 10.1186/1472-6963-14-284.
6
Real-life use of vitamin D3-fortified bread and milk during a winter season: the effects of CYP2R1 and GC genes on 25-hydroxyvitamin D concentrations in Danish families, the VitmaD study.丹麦家庭中 CYP2R1 和 GC 基因对 25-羟维生素 D 浓度的影响:冬季使用强化维生素 D3 的面包和牛奶的实际效果,VitmaD 研究。
Genes Nutr. 2014 Jul;9(4):413. doi: 10.1007/s12263-014-0413-7. Epub 2014 Jun 17.
7
Vitamin D fortified bread improves pain and physical function domains of quality of life in nursing home residents.维生素D强化面包可改善养老院居民生活质量中的疼痛和身体功能方面。
J Med Food. 2014 May;17(5):625-31. doi: 10.1089/jmf.2012.0210.
8
Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men.维生素D及维生素D类似物用于预防绝经后女性和老年男性骨折
Cochrane Database Syst Rev. 2014 Apr 14;2014(4):CD000227. doi: 10.1002/14651858.CD000227.pub4.
9
Cost-effectiveness analysis of hip fracture prevention with vitamin D supplementation: a Markov micro-simulation model applied to the French population over 65 years old without previous hip fracture.维生素 D 补充预防髋部骨折的成本效益分析:适用于无既往髋部骨折的 65 岁以上法国人群的 Markov 微观模拟模型。
Osteoporos Int. 2014 Jun;25(6):1797-806. doi: 10.1007/s00198-014-2698-1. Epub 2014 Apr 2.
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Guidelines for optimizing design and analysis of clinical studies of nutrient effects.营养素影响的临床研究优化设计和分析指南
Nutr Rev. 2014 Jan;72(1):48-54. doi: 10.1111/nure.12090. Epub 2013 Dec 13.

德国预防骨折的维生素 D 和钙强化食品的经济评估。

Economic evaluation of vitamin D and calcium food fortification for fracture prevention in Germany.

机构信息

1Department of Osteology and Biomechanics,University Medical Center Hamburg-Eppendorf,Martinistraße 52,D-20246 Hamburg,Germany.

2Department of Health Economics and Health Services Research,Hamburg Center for Health Economics,University Medical Center Hamburg-Eppendorf,Hamburg,Germany.

出版信息

Public Health Nutr. 2017 Jul;20(10):1874-1883. doi: 10.1017/S1368980015003171. Epub 2015 Nov 16.

DOI:10.1017/S1368980015003171
PMID:26568196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10261623/
Abstract

OBJECTIVE

The study evaluates the economic benefit of population-wide vitamin D and Ca food fortification in Germany.

DESIGN

Based on a spreadsheet model, we compared the cost of a population-wide vitamin D and Ca food-fortification programme with the potential cost savings from prevented fractures in the German female population aged 65 years and older.

SETTING

The annual burden of disease and the intervention cost were assessed for two scenarios: (i) no food fortification; and (ii) voluntary food fortification with 20 µg (800 IU) of cholecalciferol (vitamin D3) and 200 mg of Ca. The analysis considered six types of fractures: hip, clinical vertebral, humerus, wrist, other femur and pelvis.

SUBJECTS

Subgroups of the German population defined by age and sex.

RESULTS

The implementation of a vitamin D and Ca food-fortification programme in Germany would lead to annual net cost savings of €315 million and prevention of 36 705 fractures in the target population.

CONCLUSIONS

Vitamin D and Ca food fortification is an economically beneficial preventive health strategy that has the potential to reduce the future health burden of osteoporotic fractures in Germany. The implementation of a vitamin D and Ca food-fortification programme should be a high priority for German health policy makers because it offers substantial cost-saving potential for the German health and social care systems.

摘要

目的

本研究评估了在德国开展全民维生素 D 和钙食品强化的经济效益。

设计

基于电子表格模型,我们比较了在德国 65 岁及以上女性人群中开展全民维生素 D 和钙食品强化计划的成本与预防骨折带来的潜在成本节约。

设置

在两种情况下评估了年度疾病负担和干预成本:(i)不进行食品强化;(ii)自愿进行食品强化,添加 20µg(800IU)胆钙化醇(维生素 D3)和 200mg 钙。分析考虑了六种类型的骨折:髋部、临床椎体、肱骨、腕部、其他股骨和骨盆。

受试者

按年龄和性别定义的德国人群亚组。

结果

在德国实施维生素 D 和钙食品强化计划将带来 3.15 亿欧元的年度净成本节约,并预防目标人群中 36705 例骨折。

结论

维生素 D 和钙食品强化是一种具有经济效益的预防健康策略,有可能降低德国骨质疏松性骨折的未来健康负担。德国卫生政策制定者应高度重视开展维生素 D 和钙食品强化计划,因为它为德国卫生和社会保健系统带来了巨大的成本节约潜力。