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2012年至2014年间中国急性呼吸道感染儿童中肠道病毒D68的流行情况及分子特征

Prevalence and molecular characterizations of enterovirus D68 among children with acute respiratory infection in China between 2012 and 2014.

作者信息

Xiao Qiuyan, Ren Luo, Zheng Shouyan, Wang Lili, Xie Xiaohong, Deng Yu, Zhao Yao, Zhao Xiaodong, Luo Zhengxiu, Fu Zhou, Huang Ailong, Liu Enmei

机构信息

Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, 400014, China.

Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.

出版信息

Sci Rep. 2015 Nov 16;5:16639. doi: 10.1038/srep16639.

DOI:10.1038/srep16639
PMID:26568267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4644992/
Abstract

EV-D68 is associated with respiratory tract infections (RTIs). Since its first isolation, EV-D68 has been detected sporadically. However, the US and Canada have experienced outbreaks of EV-D68 infections between August and December 2014. This study aimed to investigate the molecular epidemiology and clinical characteristics of EV-D68 in Chongqing, Southwestern China. From January 2012 to November 2014, 1876 nasopharyngeal aspirate specimens (NPAs) were collected from hospitalized children with RTIs. Among the 1876 NPAs, EV-D68 was detected in 19 samples (1.0%, 19/1876). Of these, 13 samples were detected in September and October 2014 (9.8%, 13/132). Phylogenetic analysis showed that all 13 strains detected in the 2014 Chongqing had high homology with the main strains of the 2014 US outbreak. Among the children with EV-D68 infection, 13 (68%) had a history of recurrent wheezing. A total of 13 children had a discharge diagnosis of asthma. Of these, 11 children were diagnosed with acute asthma exacerbation. EV-D68 was the predominant pathogen that evoked asthma exacerbation in September and October 2014. In conclusion, our results found that a history of recurrent wheezing may be a risk factor for the detection of EV-D68 and viral-induced asthma exacerbation may be a clinical feature of EV-D68 infection.

摘要

肠道病毒D68型（EV-D68）与呼吸道感染（RTIs）相关。自首次分离以来，EV-D68一直呈散发性检测到。然而，美国和加拿大在2014年8月至12月期间经历了EV-D68感染的暴发。本研究旨在调查中国西南部重庆地区EV-D68的分子流行病学和临床特征。2012年1月至2014年11月，从住院的呼吸道感染儿童中收集了1876份鼻咽抽吸物标本（NPAs）。在这1876份NPAs中，19份样本（1.0%，19/1876）检测到EV-D68。其中，13份样本在2014年9月和10月检测到（9.8%，13/132）。系统发育分析表明，2014年重庆检测到的所有13株毒株与2014年美国暴发的主要毒株具有高度同源性。在EV-D68感染儿童中，13名（68%）有反复喘息病史。共有13名儿童出院诊断为哮喘。其中，11名儿童被诊断为急性哮喘加重。EV-D68是2014年9月和10月引起哮喘加重的主要病原体。总之，我们的结果发现反复喘息病史可能是检测到EV-D68的危险因素，病毒诱导的哮喘加重可能是EV-D68感染的临床特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e40f/4644992/608723a8b263/srep16639-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e40f/4644992/c5e81ef51dde/srep16639-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e40f/4644992/9f905abae3b3/srep16639-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e40f/4644992/5bf19ff15a95/srep16639-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e40f/4644992/608723a8b263/srep16639-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e40f/4644992/c5e81ef51dde/srep16639-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e40f/4644992/9f905abae3b3/srep16639-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e40f/4644992/5bf19ff15a95/srep16639-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e40f/4644992/608723a8b263/srep16639-f4.jpg

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