Deschasaux Mélanie, Souberbielle Jean-Claude, Latino-Martel Paule, Sutton Angela, Charnaux Nathalie, Druesne-Pecollo Nathalie, Galan Pilar, Hercberg Serge, Le Clerc Sigrid, Kesse-Guyot Emmanuelle, Ezzedine Khaled, Touvier Mathilde
1Sorbonne Paris Cité Epidemiology and Statistics Research Center,Inserm U1153,INRA U1125,Conservatoire National des Arts et Métiers (CNAM),Nutritional Epidemiology Research Team (EREN),Paris 13 University,93017 Bobigny,France.
2Physiology Department,Necker Hospital,Inserm U845,75015 Paris,France.
Br J Nutr. 2016 Jan 28;115(2):305-14. doi: 10.1017/S0007114515004353. Epub 2015 Nov 16.
Mechanistic hypotheses suggest that vitamin D and the closely related parathyroid hormone (PTH) may be involved in prostate carcinogenesis. However, epidemiological evidence is lacking for PTH and inconsistent for vitamin D. Our objectives were to prospectively investigate the association between vitamin D status, vitamin D-related gene polymorphisms, PTH and prostate cancer risk. A total of 129 cases diagnosed within the Supplémentation en Vitamines et Minéraux Antioxydants cohort were included in a nested case-control study and matched to 167 controls (13 years of follow-up). 25-Hydroxyvitamin D (25(OH)D) and PTH concentrations were assessed from baseline plasma samples. Conditional logistic regression models were computed. Higher 25(OH)D concentration was associated with decreased risk of prostate cancer (ORQ4 v. Q1 0·30; 95 % CI 0·12, 0·77; P trend=0·007). PTH concentration was not associated with prostate cancer risk (P trend=0·4) neither did the studied vitamin D-related gene polymorphisms. In this prospective study, prostate cancer risk was inversely associated with 25(OH)D concentration but not with PTH concentration. These results bring a new contribution to the understanding of the relationship between vitamin D and prostate cancer, which deserves further investigation.
机制假说表明，维生素D和密切相关的甲状旁腺激素（PTH）可能参与前列腺癌的发生。然而，关于PTH的流行病学证据不足，关于维生素D的证据也不一致。我们的目的是前瞻性研究维生素D状态、维生素D相关基因多态性、PTH与前列腺癌风险之间的关联。在抗氧化维生素和矿物质补充队列中确诊的129例病例被纳入一项巢式病例对照研究，并与167名对照匹配（随访13年）。从基线血浆样本中评估25-羟维生素D（25(OH)D）和PTH浓度。计算条件逻辑回归模型。较高的25(OH)D浓度与前列腺癌风险降低相关（四分位数4与四分位数1相比的比值比为0·30；95%可信区间为0·12, 0·77；P趋势=0·007）。PTH浓度与前列腺癌风险无关（P趋势=0·4），所研究的维生素D相关基因多态性也与前列腺癌风险无关。在这项前瞻性研究中，前列腺癌风险与25(OH)D浓度呈负相关，但与PTH浓度无关。这些结果为理解维生素D与前列腺癌之间的关系提供了新的贡献，值得进一步研究。
