Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Sci Rep. 2016 Dec 13;6:38962. doi: 10.1038/srep38962.
Vitamin D can exert anticancer effect beyond bone and calcium metabolism. We aimed to investigate whether postoperative vitamin D supplementation affects quality of life (QOL) and survival in esophageal cancer (EC) patients. We utilized the widely used EORTC QLQ-C30 and QLQ-OES18 to assess QOL at EC diagnosis and 24 months after surgery. Generalized estimating equations (GEEs) were used to analysis the association of vitamin D supplement use with QOL. Kaplan-Meier method and Cox regression model were used to evaluate the prognostic value of vitamin D supplementation. The notably improved QOL were found among vitamin D supplementation users compared with non-users (p < 0.05). Kaplan-Meier analysis revealed that vitamin D supplement use was significantly associated with improved disease-free survival (DFS) (p = 0.030), but not related to overall survival (OS) (p = 0.303). The multivariable analysis further demonstrated vitamin D supplement use as an independent prognostic factor for DFS (p = 0.040; HR 0.610; 95% CI 0.381-0.978). In conclusion, these results showed that vitamin D supplement use could serve as a promising intervention to enhancing QOL and prolonging DFS in EC.
维生素 D 除了对骨骼和钙代谢有抗癌作用外。我们旨在研究术后维生素 D 补充是否会影响食管癌（EC）患者的生活质量（QOL）和生存。我们使用广泛使用的 EORTC QLQ-C30 和 QLQ-OES18 在 EC 诊断和手术后 24 个月时评估 QOL。广义估计方程（GEE）用于分析维生素 D 补充剂使用与 QOL 的关系。 Kaplan-Meier 方法和 Cox 回归模型用于评估维生素 D 补充的预后价值。与非使用者相比，维生素 D 补充使用者的 QOL 明显改善（p < 0.05）。Kaplan-Meier 分析表明，维生素 D 补充剂的使用与无病生存率（DFS）的改善显著相关（p = 0.030），但与总生存率（OS）无关（p = 0.303）。多变量分析进一步证明，维生素 D 补充剂的使用是 DFS 的独立预后因素（p = 0.040；HR 0.610；95%CI 0.381-0.978）。总之，这些结果表明，维生素 D 补充剂的使用可能是一种有前途的干预措施，可以提高 EC 患者的生活质量并延长 DFS。
