Jäger Manuel, Minnaard Adriaan J
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
Chem Commun (Camb). 2016 Jan 14;52(4):656-64. doi: 10.1039/c5cc08199h.
Selective modification of unprotected carbohydrates is difficult due to the similar reactivity of the hydroxyl groups. In carbohydrate synthesis, therefore, even straightforward transformations often require multiple synthetic steps. The development of selective methods for carbohydrate modification is consequently highly desired. This review describes the methods for the regio- and chemoselective carbohydrate modification, with a focus on novel approaches that mainly apply transition metal catalysis and organocatalysis, and discusses the challenges and opportunities in this field.
由于羟基的反应活性相似，对未保护的碳水化合物进行选择性修饰具有挑战性。因此，在碳水化合物合成中，即使是简单的转化通常也需要多个合成步骤。因此，迫切需要开发用于碳水化合物修饰的选择性方法。本综述描述了区域和化学选择性碳水化合物修饰的方法，重点介绍了主要应用过渡金属催化和有机催化的新方法，并讨论了该领域的挑战和机遇。
