School of Chemistry, University of Bristol , Bristol, U.K. , BS8 1TS.
Environ Sci Technol. 2015 Dec 15;49(24):14512-21. doi: 10.1021/acs.est.5b01930. Epub 2015 Nov 16.
Inhalation of elevated levels of particulate air pollution has been shown to elicit the onset of adverse health effects in humans, where the magnitude of the response is a product of where in the lung the particulate dose is delivered. At any point in time during inhalation the depositional flux of the aerosol is a function of the radius of the droplet, thus a detailed understanding of the rate and magnitude of the mass flux of water to the droplet during inhalation is crucial. In this study, we assess the impact of aerosol hygroscopicity on deposited dose through the inclusion of a detailed treatment of the mass flux of water to account for the dynamics of particle size in a modified version of the standard International Commission on Radiological Protection (ICRP) whole lung deposition model. The ability to account for the role of the relative humidity (RH) of the aerosol prior to, and during, inhalation on the deposition pattern is explored, and found to have a significant effect on the deposition pattern. The model is verified by comparison to previously published measurements, and used to demonstrate that ambient RH affects where in the lung indoor particulate air pollution is delivered.
吸入高水平的颗粒物空气污染已被证明会引起人类健康的不良影响，而反应的程度是颗粒物剂量在肺部输送的位置的产物。在吸入过程中的任何时刻，气溶胶的沉积通量都是液滴半径的函数，因此，深入了解吸入过程中水分向液滴的质量通量的速率和幅度至关重要。在这项研究中，我们通过包括对水分质量通量的详细处理来评估气溶胶吸湿性对沉积剂量的影响，以在标准国际辐射防护委员会（ICRP）全肺沉积模型的修改版本中解释颗粒尺寸动力学。探讨了在吸入前后，气溶胶的相对湿度（RH）对沉积模式的作用的能力，并发现它对沉积模式有显著影响。通过与以前发表的测量结果进行比较来验证模型，并使用它来说明环境 RH 会影响室内颗粒物空气污染在肺部的输送位置。
