特纳综合征女性的生殖问题
Reproductive Issues in Women with Turner Syndrome.
作者信息
Folsom Lisal J, Fuqua John S
机构信息
Division of Endocrinology and Metabolism, Department of Medicine, Indiana University School of Medicine, 541 N. Clinical Drive CL 365, Indianapolis, IN 46202, USA; Section of Pediatric Endocrinology and Diabetology, Department of Pediatrics, Riley Hospital for Children, 705 Riley Hospital Drive, Room 5960, Indianapolis, IN 46202, USA.
Section of Pediatric Endocrinology and Diabetology, Department of Pediatrics, Riley Hospital for Children, 705 Riley Hospital Drive, Room 5960, Indianapolis, IN 46202, USA.
出版信息
Endocrinol Metab Clin North Am. 2015 Dec;44(4):723-37. doi: 10.1016/j.ecl.2015.07.004. Epub 2015 Sep 3.
Turner syndrome is one of the most common chromosomal abnormalities affecting female infants. The severity of clinical manifestations varies and it affects multiple organ systems. Women with Turner syndrome have a 3-fold increase in mortality, which becomes even more pronounced in pregnancy. Reproductive options include adoption or surrogacy, assisted reproductive techniques, and in rare cases spontaneous pregnancy. Risks for women with Turner syndrome during pregnancy include aortic disorders, hepatic disease, thyroid disease, type 2 diabetes, and cesarean section delivery. Providers must be familiar with the risks and recommendations in caring for women with Turner syndrome of reproductive age.
特纳综合征是影响女婴的最常见染色体异常疾病之一。临床表现的严重程度各不相同，且会影响多个器官系统。患有特纳综合征的女性死亡率增加了两倍，在孕期更为明显。生殖选择包括领养或代孕、辅助生殖技术，极少数情况下为自然受孕。患有特纳综合征的女性在孕期面临的风险包括主动脉疾病、肝脏疾病、甲状腺疾病、2型糖尿病和剖宫产。医疗服务提供者必须熟悉照顾育龄期特纳综合征女性的风险及建议。
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