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特纳综合征(单体X)妊娠的成功管理:来自越南的基于罕见病症的学习经验。

Successful management of pregnancy in Turner syndrome (Monosomy X): A rare condition-based learning experience from Vietnam.

作者信息

Bich Trinh Ngoc, Dinh Bao Vuong Anh, Nhon Nguyen Phuc

机构信息

Department of High-Risk Pregnancy, Tu Du Hospital, Ho Chi Minh City, Vietnam.

Tu Du Clinical Research Unit (TD-CRU), Tu Du Hospital, Ho Chi Minh City, Vietnam.

出版信息

Int J Reprod Biomed. 2024 Jul 8;22(5):411-416. doi: 10.18502/ijrm.v22i5.16442. eCollection 2024 May.

DOI:10.18502/ijrm.v22i5.16442
PMID:39091431
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11290197/
Abstract

BACKGROUND

Turner syndrome (TS) is recognized with partial or complete loss of the second sex chromosome, occurring in approximately one in 2500 live births, and related to high failure of pregnancy. However, along with the advantage of assisted reproductive technology, the cases of TS pregnant women have been recently addressed worldwide. Therefore, the reproductive health of TS pregnant women should be a concern by physicians and obstetricians, particularly, in the low-middle income countries with low-resource settings.

CASE PRESENTATION

Here, we describe a rare case of term pregnancy on a TS woman (45, XO) receiving oocyte donation at a private fertility center. Later, the woman was monitored uneventfully during antenatal care and hospitalized at our center for a cesarean delivery with favorable pregnancy outcomes at term.

CONCLUSION

To our knowledge, this is the first report relating to a particular pathology in Vietnam. Through this case report, we would like to emphasize the novel opportunity for TS women desiring parents, thus raising an appropriate awareness of healthcare providers.

摘要

背景

特纳综合征(TS)表现为第二条性染色体部分或完全缺失,在大约每2500例活产中出现1例,且与高妊娠失败率相关。然而,随着辅助生殖技术的发展,TS孕妇的病例近来在全球范围内受到关注。因此,TS孕妇的生殖健康应受到医生和产科医生的关注,尤其是在资源匮乏的中低收入国家。

病例报告

在此,我们描述了一例罕见病例,一名45,XO的TS女性在一家私立生育中心接受卵母细胞捐赠后足月妊娠。之后,该女性在产前检查期间得到顺利监测,并在我们中心住院接受剖宫产,足月时妊娠结局良好。

结论

据我们所知,这是越南首例关于特定病理情况的报告。通过本病例报告,我们想强调为渴望成为父母的TS女性带来的新机会,从而提高医疗服务提供者的适当认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9000/11290197/845a551b1f3f/ijrb-22-411-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9000/11290197/227052ba4941/ijrb-22-411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9000/11290197/5cbe0a020fe0/ijrb-22-411-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9000/11290197/b8a2463504ef/ijrb-22-411-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9000/11290197/845a551b1f3f/ijrb-22-411-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9000/11290197/227052ba4941/ijrb-22-411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9000/11290197/5cbe0a020fe0/ijrb-22-411-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9000/11290197/b8a2463504ef/ijrb-22-411-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9000/11290197/845a551b1f3f/ijrb-22-411-g004.jpg

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本文引用的文献

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Growth in girls with Turner syndrome.特纳综合征女孩的生长情况。
Front Endocrinol (Lausanne). 2023 Jan 12;13:1068128. doi: 10.3389/fendo.2022.1068128. eCollection 2022.
2
Reproductive health in Turner syndrome: A narrative review.特纳综合征的生殖健康:叙事性综述。
Prenat Diagn. 2023 Feb;43(2):261-271. doi: 10.1002/pd.6261. Epub 2022 Nov 12.
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Why Turner patients with 45, X monosomy should not be excluded from fertility preservation services.特纳综合征患者 45,X 单体型不应被排除在生育力保存服务之外。
Reprod Biol Endocrinol. 2022 Sep 22;20(1):143. doi: 10.1186/s12958-022-01015-z.
4
Is Fetal Hydrops in Turner Syndrome a Risk Factor for the Development of Maternal Mirror Syndrome?特纳综合征中的胎儿水肿是母体镜像综合征发生的危险因素吗?
J Clin Med. 2022 Aug 5;11(15):4588. doi: 10.3390/jcm11154588.
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Reproductive outcomes after preimplantation genetic testing in mosaic Turner syndrome: a retrospective cohort study of 100 cycles.胚胎植入前遗传学检测在嵌合体特纳综合征中的生殖结局:100 个周期的回顾性队列研究。
J Assist Reprod Genet. 2021 May;38(5):1247-1253. doi: 10.1007/s10815-021-02127-y. Epub 2021 Mar 6.
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Preimplantation genetic testing for aneuploidy in patients with partial X monosomy using their own oocytes: is this a suitable indication?使用自身卵母细胞对部分 X 单体患者进行非整倍体植入前遗传学检测:这是合适的适应证吗?
Fertil Steril. 2020 Aug;114(2):346-353. doi: 10.1016/j.fertnstert.2020.04.003. Epub 2020 Jul 15.
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Cardiovascular outcomes of pregnancy in Turner syndrome.特纳综合征患者妊娠的心血管结局。
Heart. 2021 Jan;107(1):61-66. doi: 10.1136/heartjnl-2020-316719. Epub 2020 Jul 15.
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Progress in Fertility Preservation Strategies in Turner Syndrome.特纳综合征生育力保存策略的进展
Front Med (Lausanne). 2020 Jan 24;7:3. doi: 10.3389/fmed.2020.00003. eCollection 2020.
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A case report of Turner syndrome associated with fetal nuchal cystic hygroma and bilateral syndactyly of the hands and feet.特纳综合征合并胎儿颈项透明层囊状水肿及手足并指(趾)畸形 1 例报告
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