Viegas Susana, Veiga Luísa, Almeida Ana, dos Santos Mateus, Carolino Elisabete, Viegas Carla
1.Environment and Health RG, Lisbon School of Health Technology, Polytechnic Institute of Lisbon, Av. D. João II, lote 4.69.01, Parque das Nações, 1990-096 Lisboa, Portugal; 2.Centro de Investigação em Saúde Pública (CISP/ENSP/UNL), 1600-560 Lisbon, Portugal;
3.Lisbon School of Health Technology, Polytechnic Institute of Lisbon, Lisbon, Portugal;
Ann Occup Hyg. 2016 Mar;60(2):176-83. doi: 10.1093/annhyg/mev077. Epub 2015 Nov 13.
Aflatoxin B1 (AFB1) is a secondary metabolite produced by the fungi Aspergillus flavus and is the most potent hepatocarcinogen known in mammals and has been classified by the International Agency of Research on Cancer as Group 1 carcinogen. Although dietary exposure to AFB1 has been extensively documented, there are still few studies dedicated to the problem of occupational exposure. Considering recent findings regarding AFB1 occupational exposure in poultry production, it was considered relevant to clarify if there is also exposure in poultry slaughterhouses. Occupational exposure assessment to AFB1 was done with a biomarker of internal dose that measures AFB1 in the serum by enzyme-linked immunosorbent assay. Thirty workers from a slaughterhouse were enrolled in this study. A control group (n = 30) was also considered in order to know AFB1 background levels for Portuguese population. Fourteen workers (47.0%) showed detectable levels of AFB1 with values from 1.06 to 4.03ng ml(-1), with a mean value of 1.73ng ml(-1). No AFB1 was detected in serum of individuals used as controls. Despite uncertainties regarding the exposure route that is contributing more to exposure (inhalation or dermal) is possible to state that exposure to AFB1 is occurring in the slaughterhouse studied. It seems that reducing AFB1 contamination in poultry production can have a positive result in this occupational setting.
黄曲霉毒素B1（AFB1）是由黄曲霉真菌产生的一种次生代谢产物，是哺乳动物中已知的最具强效的肝癌致癌物，已被国际癌症研究机构列为1类致癌物。尽管饮食中接触AFB1已有大量文献记载，但专门针对职业接触问题的研究仍然很少。考虑到近期有关家禽生产中AFB1职业接触的研究结果，有必要弄清楚家禽屠宰场是否也存在接触情况。通过一种内部剂量生物标志物对AFB1职业接触进行评估，该生物标志物通过酶联免疫吸附测定法测量血清中的AFB1。一家屠宰场的30名工人参与了本研究。还设立了一个对照组（n = 30），以了解葡萄牙人群的AFB1背景水平。14名工人（47.0%）的AFB1检测值在1.06至4.03 ng/ml之间，平均值为1.73 ng/ml。对照组个体的血清中未检测到AFB1。尽管对于哪种接触途径（吸入或皮肤接触）对接触的影响更大尚不确定，但可以确定在所研究的屠宰场中存在AFB1接触情况。似乎减少家禽生产中的AFB1污染在这种职业环境中可能会产生积极效果。
