Elia Roberto, Guo Jin, Budijono Stephanie, Normand Valery, Benczédi Daniel, Omenetto Fiorenzo, Kaplan David L
Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155.
Firmenich Inc., Plainsboro, New Jersey 08536.
J Coat Technol Res. 2015 Jul;12(4):793-799. doi: 10.1007/s11998-015-9668-1. Epub 2015 May 2.
Various techniques have been employed to entrap fragrant oils within microcapsules or microparticles in the food, pharmaceutical, and chemical industries for improved stability and delivery. In the present work we describe the use of silk protein microparticles for encapsulating fragrant oils using ambient processing conditions to form an all-natural biocompatible matrix. These microparticles are stabilized via physical crosslinking, requiring no chemical agents, and are prepared with aqueous and ambient processing conditions using polyvinyl alcohol-silk emulsions. The particles were loaded with fragrant oils via direct immersion of the silk particles within an oil bath. The oil-containing microparticles were coated using alternating silk and polyethylene oxide layers to control the release of the oil from the microspheres. Particle morphology and size, oil loading capacity, release rates as well as silk-oil interactions and coating treatments were characterized. Thermal analysis demonstrated that the silk coatings can be tuned to alter both retention and release profiles of the encapsulated fragrance. These oil containing particles demonstrate the ability to adsorb and controllably release oils, suggesting a range of potential applications including cosmetic and fragrance utility.
在食品、制药和化工行业中，人们采用了各种技术将香料油包裹在微胶囊或微粒中，以提高其稳定性和递送效果。在本研究中，我们描述了利用丝蛋白微粒在环境加工条件下包裹香料油，形成全天然生物相容性基质的方法。这些微粒通过物理交联得以稳定，无需化学试剂，并且是在水性和环境加工条件下使用聚乙烯醇 - 丝乳液制备而成。通过将丝颗粒直接浸入油浴中，使微粒负载香料油。使用交替的丝层和聚环氧乙烷基层对含油微粒进行包衣，以控制油从微球中的释放。对颗粒形态和尺寸、载油能力、释放速率以及丝 - 油相互作用和包衣处理进行了表征。热分析表明，可以调整丝包衣来改变包封香料的保留和释放特性。这些含油颗粒展现出吸附和可控释放油的能力，表明其在包括化妆品和香料用途在内的一系列潜在应用中具有应用价值。
