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精索静脉曲张作为男性不育的一个原因——当前的治疗技术

Varicocele as a source of male infertility - current treatment techniques.

作者信息

Kupis Łukasz, Dobroński Piotr Artur, Radziszewski Piotr

机构信息

Warsaw Medical University, Department of Urology, Poland.

出版信息

Cent European J Urol. 2015;68(3):365-70. doi: 10.5173/ceju.2015.642. Epub 2015 Oct 15.

DOI:10.5173/ceju.2015.642
PMID:26568883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4643713/
Abstract

To establish the extent of varicocele as the cause of infertility in men and compare the various techniques of treatment. We searched PubMed and the Cochrane Library database using varicocele, male infertility, varicocelectomy as keywords. Varicocele seems to be a growing problem considered to be one of the most common causes of male infertility in recent times. Nevertheless, its role remains unclear. The best treatment option seems to be microscopic surgery - the most effective and linked to rare surgical complications. But the greatest clinical problem remains the selection of patients to treat - recently it is believed that varicocelectomy is a possibly advisable option in patients with clinical varicocele and seminal parameter impairment [1]. More high-quality, multicenter, long-term randomized controlled trials (RCT's) are required to verify the findings.

摘要

确定精索静脉曲张作为男性不育原因的程度,并比较各种治疗技术。我们使用精索静脉曲张、男性不育、精索静脉结扎术作为关键词在PubMed和Cochrane图书馆数据库中进行了检索。精索静脉曲张似乎是一个日益严重的问题,被认为是近年来男性不育最常见的原因之一。然而,其作用仍不明确。最佳治疗选择似乎是显微手术——最有效且与罕见的手术并发症相关。但最大的临床问题仍然是患者的选择——最近有人认为,对于有临床精索静脉曲张和精液参数受损的患者,精索静脉结扎术可能是一个可取的选择[1]。需要更多高质量、多中心、长期的随机对照试验(RCT)来验证这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dcd/4643713/247f2704b4ad/CEJU-68-00642-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dcd/4643713/9f524bad7c93/CEJU-68-00642-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dcd/4643713/247f2704b4ad/CEJU-68-00642-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dcd/4643713/9f524bad7c93/CEJU-68-00642-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dcd/4643713/247f2704b4ad/CEJU-68-00642-g002.jpg

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Varicocele as a source of male infertility - current treatment techniques.精索静脉曲张作为男性不育的一个原因——当前的治疗技术
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2
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本文引用的文献

1
The role of oxidative stress and antioxidants in male fertility.氧化应激和抗氧化剂在男性生育能力中的作用。
Cent European J Urol. 2013;66(1):60-7. doi: 10.5173/ceju.2013.01.art19. Epub 2013 Apr 26.
2
Adolescent varicocelectomy: does artery sparing influence recurrence rate and/or catch-up growth?青少年精索静脉曲张手术:保留动脉是否会影响复发率和/或追赶生长?
Andrology. 2014 Mar;2(2):159-64. doi: 10.1111/j.2047-2927.2013.00142.x. Epub 2013 Dec 13.
3
Laparoscopic varicocelectomy in infertile men: does age matter?不育男性的腹腔镜下精索静脉曲张切除术:年龄有影响吗?
Comparison of SPAG11A gene expression in infertile men with grade 1 and 2 varicocele before and after treatment.
比较精索静脉曲张 1 级和 2 级患者治疗前后 SPAG11A 基因的表达。
JBRA Assist Reprod. 2024 Aug 26;28(3):405-409. doi: 10.5935/1518-0557.20220060.
4
Negative effect of varicocele on sperm mitochondrial dysfunction: A cross-sectional study.精索静脉曲张对精子线粒体功能障碍的负面影响:一项横断面研究。
Int J Reprod Biomed. 2023 May 8;21(4):323-332. doi: 10.18502/ijrm.v21i4.13271. eCollection 2023 May.
5
Comparison of the effects of coenzyme Q10 and Centrum multivitamins on semen parameters, oxidative stress markers, and sperm DNA fragmentation in infertile men with idiopathic oligoasthenospermia.辅酶Q10与善存多种维生素对特发性少弱精子症不育男性精液参数、氧化应激标志物及精子DNA碎片的影响比较
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6
Assessing information on YouTube™ as a quality source for the treatment of varicoceles.评估YouTube™上关于精索静脉曲张治疗的信息作为优质信息来源的情况。
Indian J Urol. 2021 Oct-Dec;37(4):339-344. doi: 10.4103/iju.iju_201_21. Epub 2021 Oct 1.
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Surgical or radiological treatment for varicoceles in subfertile men.对不育男性精索静脉曲张的手术或放射治疗。
Cochrane Database Syst Rev. 2021 Apr 23;4(4):CD000479. doi: 10.1002/14651858.CD000479.pub6.
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Improvement of sperm morphology after surgical varicocele repair.精索静脉曲张手术后精子形态的改善。
Andrology. 2021 Jul;9(4):1176-1184. doi: 10.1111/andr.13012. Epub 2021 May 6.
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[Testicular sperm extraction in male infertility : Indications, success rates, practical implementation, and possible complications].[男性不育症中的睾丸精子提取:适应症、成功率、实际操作及可能的并发症]
Urologe A. 2021 Jul;60(7):921-931. doi: 10.1007/s00120-021-01480-1. Epub 2021 Mar 3.
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Medicine (Baltimore). 2020 Dec 18;99(51):e23662. doi: 10.1097/MD.0000000000023662.
Urol Int. 2013;91(2):192-6. doi: 10.1159/000350860. Epub 2013 Jul 6.
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Open non-microsurgical, laparoscopic or open microsurgical varicocelectomy for male infertility: a meta-analysis of randomized controlled trials.开放非显微手术、腹腔镜或开放显微手术精索静脉结扎术治疗男性不育症:随机对照试验的荟萃分析。
BJU Int. 2012 Nov;110(10):1536-42. doi: 10.1111/j.1464-410X.2012.11093.x. Epub 2012 May 29.
6
European Association of Urology guidelines on Male Infertility: the 2012 update.欧洲泌尿外科学会男性不育症指南:2012 年更新版。
Eur Urol. 2012 Aug;62(2):324-32. doi: 10.1016/j.eururo.2012.04.048. Epub 2012 May 3.
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Patterns of infertility in Poland - multicenter study.波兰不孕症模式——多中心研究
Neuro Endocrinol Lett. 2011;32(6):799-804.
8
Are varicoceles associated with increased deoxyribonucleic acid fragmentation?精索静脉曲张是否与脱氧核糖核酸碎片化增加有关?
Fertil Steril. 2011 Dec;96(6):1283-7. doi: 10.1016/j.fertnstert.2011.10.016. Epub 2011 Oct 28.
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Effect of varicocele on sperm function and semen oxidative stress.精索静脉曲张对精子功能和精液氧化应激的影响。
BJU Int. 2012 Jan;109(2):259-65. doi: 10.1111/j.1464-410X.2011.10240.x. Epub 2011 May 18.
10
Review of current varicocelectomy techniques and their outcomes.精索静脉曲张手术技术及其疗效的研究进展。
BJU Int. 2011 Oct;108(7):1157-72. doi: 10.1111/j.1464-410X.2010.09959.x. Epub 2011 Mar 24.