Sacks Joelle D, Barbolina Maria V
Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S Wood Street, 335 College of Pharmacy Building, Chicago, IL 60612, USA.
Biomolecules. 2015 Nov 11;5(4):3051-66. doi: 10.3390/biom5043051.
CD44, a cell surface glycoprotein, has been increasingly implicated in the pathogenesis and progression of epithelial ovarian cancer, the deadliest gynecologic malignancy in women. Here, we review recent reports on the expression and function of CD44 in epithelial ovarian carcinoma. Further functional data for CD44 in peritoneal adhesion and metastatic progression and its association with stem cells is highlighted. Recent studies utilizing CD44 for therapeutic targeting are also discussed.
CD44是一种细胞表面糖蛋白，越来越多地被认为与上皮性卵巢癌（女性最致命的妇科恶性肿瘤）的发病机制和进展有关。在此，我们综述了关于CD44在上皮性卵巢癌中的表达和功能的最新报道。重点介绍了CD44在腹膜粘连和转移进展中的进一步功能数据及其与干细胞的关联。还讨论了利用CD44进行治疗靶向的最新研究。
