Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.
Clin Exp Metastasis. 2023 Apr;40(2):125-135. doi: 10.1007/s10585-023-10203-z. Epub 2023 Apr 10.
A participant in key developmental processes, the adhesion glycoprotein CD44 is also expressed in several types of malignancies and can promote metastasis. In addition, the expression of CD44 isoforms in different types of cancer such as prostate and breast cancers may facilitate bone metastases by enhancing tumorigenicity, osteomimicry, cell migration, homing to bone, and anchorage within the bone specialized domains. Moreover, there is evidence that the CD44-ICD fragments in breast cancer cells may promote the cells' osteolytic nature. Yet the mechanisms by which CD44 and its downstream effectors promote the establishment of these cells within the bone are not fully elucidated. In this review, we summarize the current data on the roles played by CD44 in cancer progression and bone metastasis and the possible effects of its interaction with the different components of the bone marrow milieu.
作为关键发育过程中的参与者，黏附糖蛋白 CD44 也在几种类型的恶性肿瘤中表达，并能促进转移。此外，CD44 异构体在不同类型的癌症（如前列腺癌和乳腺癌）中的表达可能通过增强肿瘤形成能力、骨模仿、细胞迁移、向骨归巢和在骨特定区域内附着来促进骨转移。此外，有证据表明，乳腺癌细胞中的 CD44-ICD 片段可能促进细胞的溶骨性。然而，CD44 及其下游效应物促进这些细胞在骨内建立的机制尚未完全阐明。在这篇综述中，我们总结了 CD44 在癌症进展和骨转移中的作用的最新数据，以及其与骨髓环境的不同成分相互作用的可能影响。
