Wouters M M, Boeckxstaens G E
a Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), Center of Neuroimmune interaction and Mucosal Immunology , University Hospital Leuven, KU Leuven , Leuven , Belgium.
Expert Rev Gastroenterol Hepatol. 2016;10(1):5-8. doi: 10.1586/17474124.2016.1109446. Epub 2015 Nov 16.
Psychological disorders, most notably anxiety and depressive disorders, somatization and catastrophizing, often precede or exacerbate functional gastrointestinal disorder (FGID) symptoms and correlate with symptom severity and health outcomes. Mounting evidence shows that psychological distress alters gut immunity, in particular mast cell activation, leading to a potentiation of sensory nerves and aberrant visceral pain perception. On the other hand, psychological stressors modulate the processing of incoming sensory signals by the brain, thereby contributing to FGID symptom development. A better understanding of the molecular mechanisms underlying stress-induced changes in the immune system or brain processing is crucial for the development of novel beneficial therapeutic strategies.
心理障碍，最显著的是焦虑和抑郁障碍、躯体化和灾难化思维，常常先于功能性胃肠疾病（FGID）症状出现或使其加重，并与症状严重程度和健康结果相关。越来越多的证据表明，心理困扰会改变肠道免疫，特别是肥大细胞的激活，导致感觉神经增强和异常的内脏痛觉。另一方面，心理应激源会调节大脑对传入感觉信号的处理，从而促使FGID症状的发展。更好地理解应激诱导免疫系统或大脑处理变化的分子机制，对于开发新的有效治疗策略至关重要。
