Bennett E J, Piesse C, Palmer K, Badcock C A, Tennant C C, Kellow J E
Department of Gastroenterology, Royal North Shore Hospital, Sydney, Australia.
Gut. 1998 Mar;42(3):414-20. doi: 10.1136/gut.42.3.414.
Psychological, social, and extraintestinal (somatic) disturbances are prominent features of functional gastrointestinal disorders (FGID); little attention, however, has been given to differences in the nature of these disturbances in the various FGID subgroups.
(1) To determine whether psychological, social, and extraintestinal factors are associated with specific FGID, and/or with the overall severity and extent of FGID disturbance (the number of coexistent FGID subgroups present in any individual); and (2) to determine whether chronic social stressors link gastrointestinal, extraintestinal, and emotional symptomatologies in FGID.
One hundred and eighty eight outpatients, fulfilling standard criteria for one or more functional gastroduodenal or functional bowel disorders.
Utilising detailed and objective interview and questionnaire methods, detailed gastrointestinal, extraintestinal, psychological, and social data were collected.
Chronic stressors and extraintestinal and emotional symptomatologies were prominent features of functional dyspepsia (FD) and irritable bowel syndrome (IBS) alone. These particular features were, however, highly specific for particular FD and/or IBS subgroups. The chronic threat component of social stressors predicted the nature and extent of multisystem (gastrointestinal, extraintestinal, and emotional) symptomatology.
Notable differences between the various FGID subgroups support the symptom based classification of FGID. Chronic stressor provoked psychological and extraintestinal disturbance is most specific for the FD-IBS group of syndromes.
心理、社会及肠外(躯体)功能紊乱是功能性胃肠疾病(FGID)的突出特征;然而,对于FGID各亚组中这些功能紊乱本质上的差异关注甚少。
(1)确定心理、社会及肠外因素是否与特定FGID相关,和/或与FGID功能紊乱的总体严重程度及范围(任何个体中共存的FGID亚组数量)相关;(2)确定慢性社会应激源是否将FGID中的胃肠道、肠外及情绪症状联系起来。
188例门诊患者,符合一种或多种功能性胃十二指肠疾病或功能性肠病的标准。
采用详细且客观的访谈和问卷调查方法,收集详细的胃肠道、肠外、心理及社会数据。
慢性应激源以及肠外和情绪症状仅是功能性消化不良(FD)和肠易激综合征(IBS)的突出特征。然而,这些特定特征对特定的FD和/或IBS亚组具有高度特异性。社会应激源的慢性威胁成分可预测多系统(胃肠道、肠外及情绪)症状的性质和范围。
FGID各亚组之间的显著差异支持基于症状的FGID分类。慢性应激源引发的心理和肠外功能紊乱对FD-IBS综合征组最为特异。