Felice Valeria D, Moloney Rachel D, Cryan John F, Dinan Timothy G, O'Mahony Siobhain M
Mod Trends Pharmacopsychiatry. 2015;30:103-19. doi: 10.1159/000435936. Epub 2015 Sep 18.
The high comorbidity existing between visceral pain and psychiatric disorders such as depression and anxiety is well documented and it is gaining increasing interest among scientists. When visceral pain and psychiatric disorders are comorbid, they present a more debilitating condition than each disorder alone, impacting significantly on the quality of life of these patients. Despite several groups having shown that an overlapping pathophysiology exists between visceral pain and stress-related disorders the link between them is not clear yet. Moreover, it still remains to be elucidated if psychiatric conditions predispose the individual to develop visceral hypersensitivity or vice versa. The brain-gut-microbiome axis is the bidirectional communication between the CNS and the gastrointestinal tract. Alterations at different levels of this axis have been implicated in both visceral hypersensitivity and psychiatric disorders. Here we give an overview of what it is known about comorbid visceral pain and psychiatric disorders and provide evidence of potential overlapping pathophysiological mechanisms involved. Preclinical models of comorbid visceral pain and stress-related disorders are also discussed.
内脏痛与抑郁症和焦虑症等精神疾病之间存在的高共病性已有充分记录，并且越来越受到科学家的关注。当内脏痛与精神疾病共病时，它们所呈现的状况比单独的每种疾病更具致残性，对这些患者的生活质量产生重大影响。尽管有几个研究小组表明内脏痛与应激相关疾病之间存在重叠的病理生理学，但它们之间的联系尚不清楚。此外，精神疾病是否会使个体易患内脏超敏反应，反之亦然，这一点仍有待阐明。脑-肠-微生物群轴是中枢神经系统与胃肠道之间的双向通信。该轴不同水平的改变与内脏超敏反应和精神疾病都有关联。在此，我们概述了关于共病内脏痛和精神疾病的已知情况，并提供了潜在重叠病理生理机制的证据。还讨论了共病内脏痛与应激相关疾病的临床前模型。
