Johnson G H, Taylor T D, Heid D W
University of Washington, School of Dentistry, Seattle.
J Prosthet Dent. 1989 Jun;61(6):699-703. doi: 10.1016/s0022-3913(89)80045-9.
Nystatin has been formulated in the form of a flavored pastille (troche) as an alternative to the oral suspension. This parallel, double-blind, randomized, placebo-controlled study evaluated the acceptance and effectiveness of the nystatin pastille at two different dosages. Twenty-four subjects were selected on the basis of clinical signs of denture stomatitis and culture isolation of Candida spp. Each subject was randomly assigned to one of three treatment groups (A, 200,000 units; B, 400,000 units; and C, placebo). At entry, 7 days, 14 days, and at 10 days after cessation of treatment, the clinical condition was evaluated and Gram stain smears and imprint cultures were made and analyzed. The flavored pastille was well accepted by the subjects and both dosages were shown to be effective in significantly reducing or eliminating the Candida organism during active therapy. Data from the 10-day follow-up, however, demonstrated reinfection with the organism. Thus to resolve the condition, effective therapy must include treatment of the etiologic factors of denture stomatitis along with antimicrobial therapy.
制霉菌素已被制成有味道的含片（锭剂）形式，作为口服混悬液的替代剂型。这项平行、双盲、随机、安慰剂对照研究评估了两种不同剂量的制霉菌素含片的可接受性和有效性。根据义齿性口炎的临床体征和念珠菌属的培养分离情况选择了24名受试者。每个受试者被随机分配到三个治疗组之一（A组，200,000单位；B组，400,000单位；C组，安慰剂）。在入组时、第7天、第14天以及治疗停止后第10天，评估临床状况，并制作和分析革兰氏染色涂片及压印培养物。有味道的含片很受受试者欢迎，两种剂量在积极治疗期间均显示出能有效显著减少或消除念珠菌。然而，10天随访的数据表明念珠菌再次感染。因此，为解决该病症，有效的治疗必须包括治疗义齿性口炎的病因以及抗菌治疗。
