Rai Anamika, Misra Satya Ranjan, Panda Saurav, Sokolowski Grzegorz, Mishra Lora, Das Rupsa, Lapinska Barbara
Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751003, India.
Department of Periodontics, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751003, India.
Life (Basel). 2022 Oct 22;12(11):1677. doi: 10.3390/life12111677.
Oral candidiasis is the most common opportunistic fungal infection caused by commensal species. Since there are various local and systemic predisposing factors for the disease, the treatment also varies from topical to systemic antifungal agents. Nystatin is a common antifungal agent used topically. The aim of this systematic review was to evaluate and compare the efficacy of different antifungal agents and the safety of nystatin in the treatment of oral candidiasis. Three electronic databases were searched for randomized controlled trials comparing nystatin with other anti-fungal therapies or placebo. Clinical and/or mycological cure was the outcome evaluation. A meta-analysis and descriptive study on the efficacy, treatment protocols, and safety of nystatin was also conducted. The meta-analysis included five studies, which compared the efficacy of nystatin suspensions with photodynamic therapy. A significant difference in the colony-forming units per milliliters (CFU/mL) of species was observed at 60 days intervals for both palatal mucosa and denture surfaces, with both groups favoring nystatin with low heterogeneity at a 95% confidence interval. Nystatin and photodynamic therapy were found to be equally effective for the clinical remission of denture stomatitis as well as a significant reduction of CFU/mL of species from dentures and palatal surfaces of the patients.
口腔念珠菌病是由共生菌引起的最常见的机会性真菌感染。由于该疾病存在多种局部和全身诱发因素，治疗方法也因局部和全身抗真菌药物而异。制霉菌素是一种常用的局部抗真菌药物。本系统评价的目的是评估和比较不同抗真菌药物的疗效以及制霉菌素治疗口腔念珠菌病的安全性。检索了三个电子数据库，以查找比较制霉菌素与其他抗真菌疗法或安慰剂的随机对照试验。以临床和/或真菌学治愈作为结局评估。还对制霉菌素的疗效、治疗方案和安全性进行了荟萃分析和描述性研究。荟萃分析纳入了五项研究，这些研究比较了制霉菌素混悬液与光动力疗法的疗效。在腭黏膜和义齿表面，每隔60天观察到的菌种每毫升菌落形成单位（CFU/mL）存在显著差异，两组均倾向于制霉菌素，在95%置信区间内异质性较低。发现制霉菌素和光动力疗法在义齿性口炎的临床缓解以及患者义齿和腭表面菌种CFU/mL的显著降低方面同样有效。
