MOE Key Lab of Applied Physics and Chemistry in Space, College of Science, Northwestern Polytechnic University, Xi'an 710072, China.
Carbohydr Polym. 2013 Feb 15;92(2):1357-66. doi: 10.1016/j.carbpol.2012.10.032. Epub 2012 Oct 17.
Hydrogels based on hemicellulose of wheat straw were prepared as a novel carrier for controlled drug delivery. The chemical structure and morphology of the hydrogels were characterised using FT-IR and SEM, respectively. The swelling ratios of the hydrogels were determined, and the results showed that the hydrogels were pH-responsive. The swelling kinetics of the hydrogels followed a Fickian diffusion process in media with a pH of 1.5, and water uptake was controlled collaboratively by hydrogel relaxation and water diffusion in media with pH values of 7.4 and 10.0. The degradation test of the hydrogels was conducted under simulated physiological conditions, and both hemicellulose content and the crosslinking density of the hydrogels were major factors that affected the biodegradability of the hemicellulose-based hydrogels. A comparison of the in vitro release of acetylsalicylic acid and theophylline indicated that the drug release was controlled both by the hydrogel and by the intrinsic character of the drug. According to the results presented here, hemicellulose-based hydrogels can be used in biomedical fields, especially for controlled drug release.
以麦草半纤维素为原料制备水凝胶作为一种新型药物控制释放载体。采用傅里叶变换红外光谱（FT-IR）和扫描电子显微镜（SEM）分别对水凝胶的化学结构和形态进行了表征。测定了水凝胶的溶胀比，结果表明水凝胶具有 pH 响应性。在 pH 值为 1.5 的介质中，水凝胶的溶胀动力学符合菲克扩散过程，而在 pH 值为 7.4 和 10.0 的介质中，水凝胶的溶胀主要由水凝胶的松弛和水的扩散共同控制。在模拟生理条件下对水凝胶进行了降解试验，半纤维素含量和水凝胶的交联密度是影响半纤维素基水凝胶生物降解性的主要因素。乙酰水杨酸和茶碱体外释放的比较表明，药物释放既受水凝胶的控制，也受药物内在性质的控制。根据本文的研究结果，半纤维素基水凝胶可用于生物医学领域，特别是用于控制药物释放。
