Mahil Satveer K, Capon Francesca, Barker Jonathan N
St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, London, UK.
Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King's College London, London, UK.
Semin Immunopathol. 2016 Jan;38(1):11-27. doi: 10.1007/s00281-015-0539-8. Epub 2015 Nov 16.
Over recent years, significant progress has been made in characterisation of the underlying pathogenic mechanisms in psoriasis, a common cutaneous disease that is associated with major systemic co-morbidity and reduced life expectancy. Basic science discoveries have informed the design of novel therapeutic approaches, many of which are now under evaluation in late-stage clinical trials. Here we describe the complex interplay between immune cell types and cytokine networks that acts within self-perpetuating feedback loops to drive cutaneous inflammation in psoriasis. Genetic studies have been pivotal in the construction of the disease model and more recently have uncovered a distinct aetiology for rare, pustular variants of psoriasis. The translation of mechanistic insights into potential advancements in clinical care will also be described, including several treatments that target the interleukin-23 (IL-23)/T17 immune axis.
近年来，在银屑病潜在致病机制的研究方面取得了重大进展。银屑病是一种常见的皮肤病，与主要的全身性合并症及预期寿命缩短相关。基础科学的发现为新型治疗方法的设计提供了依据，其中许多方法目前正在后期临床试验中进行评估。在此，我们描述了免疫细胞类型与细胞因子网络之间复杂的相互作用，这种相互作用在自我延续的反馈回路中发挥作用，从而引发银屑病的皮肤炎症。基因研究在构建疾病模型中起到了关键作用，并且最近还发现了银屑病罕见脓疱型变体的独特病因。我们还将阐述将机制性见解转化为临床护理潜在进展的情况，包括几种针对白细胞介素 - 23（IL - 23）/T17免疫轴的治疗方法。
