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IL36RN mutations define a severe autoinflammatory phenotype of generalized pustular psoriasis.

作者信息

Hussain Safia, Berki Dorottya M, Choon Siew-Eng, Burden A David, Allen Michael H, Arostegui Juan I, Chaves Antonio, Duckworth Michael, Irvine Alan D, Mockenhaupt Maja, Navarini Alexander A, Seyger Marieke M B, Soler-Palacin Pere, Prins Christa, Valeyrie-Allanore Laurence, Vicente M Asuncion, Trembath Richard C, Smith Catherine H, Barker Jonathan N, Capon Francesca

机构信息

Division of Genetics and Molecular Medicine, King's College London, London, United Kingdom.

Department of Dermatology, Hospital Sultanah Aminah, Johor Bahru, Malaysia.

出版信息

J Allergy Clin Immunol. 2015 Apr;135(4):1067-1070.e9. doi: 10.1016/j.jaci.2014.09.043. Epub 2014 Nov 12.

DOI:10.1016/j.jaci.2014.09.043
PMID:25458002
Abstract
摘要

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IL36RN mutations define a severe autoinflammatory phenotype of generalized pustular psoriasis.IL36RN基因突变定义了泛发性脓疱型银屑病的一种严重自身炎症表型。
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Correlation of IL36RN mutation with different clinical features of pustular psoriasis in Chinese patients.白细胞介素36受体拮抗剂（IL36RN）突变与中国脓疱型银屑病患者不同临床特征的相关性
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The genetic basis for most patients with pustular skin disease remains elusive.大多数脓疱性皮肤病患者的遗传基础仍难以捉摸。
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Association of IL36RN mutations with clinical features, therapeutic response to acitretin, and frequency of recurrence in patients with generalized pustular psoriasis.IL36RN突变与泛发性脓疱型银屑病患者的临床特征、阿维A治疗反应及复发频率的相关性
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