Woolman P S, Coutts C T, Mole D R, Dendy P P, Higenbottam T W
Department of Respiratory Physiology, Addenbrookes Hospital, Cambridge, UK.
Nucl Med Commun. 1989 Mar;10(3):171-80.
A study was made of the deposition of 99Tcm-DTPA aerosol in the components of a jet nebulizer-based aerosol production system. Three impaction devices were compared: a ball-bearing separator, a virtual impactor and a step separator. In addition a comparison was made of two types of tubing which carried aerosol from nebulizer to mouthpiece: corrugated and smooth-walled tubing. The retention of aerosol following inhalation was measured in five normal volunteers using different patterns of breathing. Using an aerosol production system which included a ball-bearing separator only a mean of 11% of the radioactivity loaded into the nebulizer was emitted as an aerosol. Some 18% remained in the ball-bearing separator. The ball-bearing and step separators produced similar total outputs (7% and 6% minimum), the step separator producing marginally higher mean output/min. The virtual impactor produced a lower output than the other two impactors studied, only 1%. A larger proportion of the aerosol output was deposited on corrugated tubing (7%) compared with smooth-walled tubing (1%). The retained fraction of the aerosol inhaled by subjects ranged from 16% to 43%. A higher fraction was retained when subjects inhaled deeply and held their breath for 10 s between each breath. The efficiency of radionuclide deposition from aerosol generator to patient ranged from 1.1% to 6% and was determined more by the retention in the subject than by choice of separator or tubing.
对基于喷射雾化器的气溶胶产生系统各组件中99锝-二乙三胺五醋酸（99Tcm-DTPA）气溶胶的沉积情况进行了一项研究。比较了三种撞击装置：滚珠轴承分离器、虚拟撞击器和阶梯分离器。此外，还比较了两种将气溶胶从雾化器输送到吸嘴的管道：波纹管和光滑壁管。在五名正常志愿者中，使用不同呼吸模式测量了吸入后气溶胶的潴留情况。使用仅包含滚珠轴承分离器的气溶胶产生系统时，雾化器中加载的放射性物质平均只有11%以气溶胶形式排出。约18%残留在滚珠轴承分离器中。滚珠轴承分离器和阶梯分离器产生的总输出量相似（最低分别为7%和6%），阶梯分离器的平均每分钟输出量略高。虚拟撞击器产生的输出量低于所研究的其他两种撞击器，仅为1%。与光滑壁管（1%）相比，更大比例的气溶胶输出沉积在波纹管上（7%）。受试者吸入的气溶胶潴留比例在16%至43%之间。当受试者深呼吸并在每次呼吸之间屏气10秒时，潴留比例更高。从气溶胶发生器到患者的放射性核素沉积效率在1.1%至6%之间，更多地取决于受试者体内的潴留情况，而非分离器或管道的选择。
