Schwartz Joseph S, Palmer James N, Adappa Nithin D
Department of Otorhinolaryngology - Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Curr Opin Otolaryngol Head Neck Surg. 2016 Feb;24(1):63-9. doi: 10.1097/MOO.0000000000000220.
This article provides a contemporary review of the management of esthesioneuroblastoma (ENB) within the context of recent surgical advancements, while highlighting the ongoing limitations and controversies surrounding this uncommon pathologic entity.
Surgical management of ENB is continuously evolving with contemporary endoscopic approaches complementing or in many cases replacing open approaches.
Complete surgical resection remains the mainstay definitive therapy for ENB. Aggressive, combined modality therapy appears to be justified in patients at greatest risk of developing recurrence based on advanced tumor stage and high pathologic grade. ENB requires prolonged surveillance following treatment given its tendency for late recurrence.
本文在近期手术进展的背景下，对嗅神经母细胞瘤（ENB）的治疗进行了当代综述，同时强调了围绕这种罕见病理实体的持续局限性和争议。
ENB的手术治疗不断发展，当代内镜方法补充或在许多情况下取代了开放手术方法。
完整的手术切除仍然是ENB的主要确定性治疗方法。对于基于晚期肿瘤分期和高病理分级而复发风险最高的患者，积极的综合治疗似乎是合理的。由于ENB有晚期复发的倾向，治疗后需要长期监测。
