He Xindi, Wang Ying
Department of Rhinology，the First Affiliated Hospital of Zhengzhou University，Zhengzhou，450052，China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Apr;35(4):338-340. doi: 10.13201/j.issn.2096-7993.2021.04.012.
To investigate the clinical characteristics and prognostic factors of esthesioneuroblastoma. The clinical data of 31 patients with esthesioneuroblastoma were retrospectively studied. The average time from first onset to diagnosis in 31 patients was 7.84 months, among which 3 patients（9.68%） had cervical lymph node metastasis at the first visit. By the end of follow-up, there were 25 coexisting cases and 6 deaths. The mean recurrence time of 6 patients was 10.6 months. There were 6 patients with distant metastasis, including 4 patients with cervical lymph node metastasis, 1 patient with liver metastasis and 1 patient with bone metastasis. Modified Kadish stage, different treatment methods, recurrence, first diagnosis of cervical lymph node metastasis, and distant metastasis were all factors affecting the prognosis of the patients. The incidence of esthesioneuroblastoma is low and the comprehensive treatment of surgery combined with radiotherapy is the optimal treatment plan. Patients with low Kadish staging, surgical combined with radiotherapy, no recurrence, no initial cervical lymph node metastasis, and no distant metastasis have a better prognosis.
探讨嗅神经母细胞瘤的临床特征及预后因素。回顾性分析31例嗅神经母细胞瘤患者的临床资料。31例患者从首次发病到确诊的平均时间为7.84个月，其中3例（9.68%）初诊时即有颈部淋巴结转移。至随访结束时，共存25例，死亡6例。6例患者的平均复发时间为10.6个月。有6例发生远处转移，其中颈部淋巴结转移4例，肝转移1例，骨转移1例。改良Kadish分期、不同治疗方法、复发、初诊时颈部淋巴结转移及远处转移均为影响患者预后的因素。嗅神经母细胞瘤发病率低，手术联合放疗的综合治疗是最佳治疗方案。Kadish分期低、手术联合放疗、无复发、初诊时无颈部淋巴结转移及无远处转移的患者预后较好。
