糖尿病患者的血清胱抑素C、慢性肾脏病标志物与视网膜病变
Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes.
作者信息
Wong Chee Wai, Teo Boon Wee, Lamoureux Ecosse, Ikram Mohammad Kamran, Wang Jie Jin, Tai E Shyong, Sethi Sunil, Wong Tien Yin, Sabanayagam Charumathi
机构信息
Singapore Eye Research Institute, Singapore National Eye Centre, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856.
Department of Medicine, Singapore National University Hospital, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074.
出版信息
J Diabetes Res. 2015;2015:404280. doi: 10.1155/2015/404280. Epub 2015 Oct 20.
PURPOSE
We examined the association of CKD defined by serum creatinine, serum cystatin C, and albuminuria with moderate diabetic retinopathy (DR).
METHODS
We examined 1,119 Indian adults with diabetes, aged 40-80 years, who participated in the Singapore Indian Eye Study (2007-2009), a population-based cross-sectional study. The associations of CKD defined by each of the three markers alone and in combination with moderate DR were examined using logistic regression models adjusted for potential confounding factors including duration of diabetes, smoking, body mass index, systolic blood pressure, and HbA1c.
RESULTS
The prevalence of moderate DR was significantly higher among those with CKD defined by triple markers (41.1%) compared to CKD defined separately by creatinine (26.6%), cystatin C (20.9%), and albuminuria (23.4%). People with CKD defined by triple markers had a fourteenfold higher odds of moderate DR (OR (95% CI) = 13.63 (6.08-30.54)) compared to those without CKD by any marker. Nearly half (48.7%) of participants with cystatin C ≥ 1.12 mg/L have moderate DR.
CONCLUSIONS
CKD defined by a triple marker panel was strongly associated with moderate DR in this Asian population with diabetes.
目的
我们研究了由血清肌酐、血清胱抑素C和蛋白尿定义的慢性肾脏病（CKD）与中度糖尿病视网膜病变（DR）之间的关联。
方法
我们对1119名年龄在40 - 80岁的印度成年糖尿病患者进行了研究，这些患者参与了新加坡印度人眼研究（2007 - 2009年），这是一项基于人群的横断面研究。使用逻辑回归模型，对包括糖尿病病程、吸烟、体重指数、收缩压和糖化血红蛋白等潜在混杂因素进行调整，研究单独使用三种标志物中的每一种以及联合使用时定义的CKD与中度DR之间的关联。
结果
与分别由肌酐（26.6%）、胱抑素C（20.9%）和蛋白尿（23.4%）定义的CKD相比，由三种标志物联合定义的CKD患者中中度DR的患病率显著更高（41.1%）。与任何标志物均未定义为CKD的患者相比，由三种标志物联合定义为CKD的患者发生中度DR的几率高出14倍（比值比（95%置信区间）= 13.63（6.08 - 30.54））。胱抑素C≥1.12 mg/L的参与者中近一半（48.7%）患有中度DR。
结论
在这个亚洲糖尿病患者群体中，由三种标志物组合定义的CKD与中度DR密切相关。
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