导致原发性骨淋巴瘤患者结局的社会经济和人口统计学因素。
Socioeconomic and demographic factors contributing to outcomes in patients with primary lymphoma of bone.
机构信息
Hofstra North Shore-LIJ School of Medicine, 500 Hofstra University, Hempstead, NY 11549, USA.
Department of Orthopaedics, North Shore Long Island Jewish Medical Center, 270-05 76th Avenue, New Hyde Park, NY 11040, USA.
出版信息
J Bone Oncol. 2014 Dec 26;4(1):32-6. doi: 10.1016/j.jbo.2014.11.002. eCollection 2015 Mar.
BACKGROUND
Primary lymphoma of bone (PLB) is a rare disease, comprising a malignant lymphoid infiltrate of bone. The goal of this study was to identify socioeconomic, demographic, and anatomic factors as prognostic indicators of survival for this disease using the Surveillance, Epidemiology, and End Results (SEER) database.
METHODS
The SEER database was used to identify a study population of 692 patients diagnosed with PLB in the United States from 1989 to 2003. Survival was analyzed using the Kaplan-Meier method, with effects of potential prognostic factors on survival analyzed using the log-rank test. Multivariable analysis was performed by Cox proportional hazards regression.
RESULTS
The overall 5-year survival rate was 49.6%, with a 10-year survival rate of 30.2%. Median overall survival was 4.9 years (95% CI: 3.9, 6.1). In multivariable analysis, age (p<0.0001), marital status (p=0.006), and appendicular vs. axial tumor location (p=0.004) were found to be independent predictors of survival.
CONCLUSIONS
This population-based study of PLB identified age, marital status, and tumor location as independent indicators of prognosis. This finding supports the clinical suspicion that an appendicular tumor location confers a better prognosis than an axial tumor location.
背景
原发性骨淋巴瘤（PLB）是一种罕见疾病，由骨内恶性淋巴样浸润组成。本研究的目的是使用监测、流行病学和最终结果（SEER）数据库，确定与生存相关的社会经济、人口统计学和解剖因素，作为该疾病的预后指标。
方法
使用 SEER 数据库，在美国从 1989 年至 2003 年确定了 692 例原发性骨淋巴瘤患者的研究人群。使用 Kaplan-Meier 方法分析生存情况，采用对数秩检验分析潜在预后因素对生存的影响。采用 Cox 比例风险回归进行多变量分析。
结果
总体 5 年生存率为 49.6%，10 年生存率为 30.2%。中位总生存期为 4.9 年（95%CI：3.9，6.1）。多变量分析显示，年龄（p<0.0001）、婚姻状况（p=0.006）和四肢与中轴肿瘤位置（p=0.004）是独立的生存预测因素。
结论
本项基于人群的原发性骨淋巴瘤研究确定了年龄、婚姻状况和肿瘤位置是独立的预后指标。这一发现支持了临床怀疑四肢肿瘤位置比中轴肿瘤位置预后更好的观点。
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