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变革创伤性脑损伤的跨专业协作成果:诊断、个性化医疗、技术创新和神经康复的新趋势

Revolutionizing cross professional collaboration outcomes in TBI: emerging trends in diagnostics, personalized medicine, technological innovations and neurorehabilitation.

作者信息

Kiyani Mubin Mustafa, Bashir Shahid, Shahzadi Benish, Khan Hamid, Butt Maisra Azhar, Hussain Syed Ali, Abualait Turki

机构信息

Shifa College of Medical Technology, Shifa Tameer-e-Millat University, Shifa International Hospitals Ltd., Gate No. 1 ،4 Pitras Bukhari Rd, H 8/4 H-8, Islamabad, Pakistan.

Neuroscience Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

出版信息

Brain Inform. 2025 Sep 2;12(1):22. doi: 10.1186/s40708-025-00271-0.

Abstract

Traumatic brain injury (TBI) is still considered a major cause of morbidity and mortality worldwide, and its prevalence is increasing daily. TBI patients are facing difficult diagnostic, management, and rehabilitative challenges. This review article represents the most relevant recent findings in all areas of TBI concerning pathophysiology, diagnostics, therapeutics, rehabilitation approaches and neuroplasticity. In recent years, the diagnosis of TBI has improved more often due to advancements in neuroimaging, biomarkers, and artificial intelligence. Pharmacological treatments, stem cell therapy, and neuroprotective strategies are also associated with a wide range of therapeutic innovations that could open new fields of acute management. Consequently, practice has also changed, and cross professional treatments have been adopted with the aid of the latest technology for acute TBI recovery. TBI management faces multiple challenges in special populations, such as pediatric patients, elderly people, and soldiers. Personalized medicine, big data analytics, and global collaboration are emphasized as future research directions. This detailed study should serve to remind researchers and clinicians alike of the ongoing need for innovation to deliver better care pathways appropriate for TBI patients.

摘要

创伤性脑损伤(TBI)仍是全球发病和死亡的主要原因,其患病率每天都在上升。TBI患者面临着诊断、管理和康复方面的难题。这篇综述文章介绍了TBI在病理生理学、诊断、治疗、康复方法和神经可塑性等所有领域的最新相关研究成果。近年来,由于神经影像学、生物标志物和人工智能的进展,TBI的诊断有了更多改善。药物治疗、干细胞治疗和神经保护策略也与一系列治疗创新相关,这些创新可能会开辟急性管理的新领域。因此,实践也发生了变化,借助最新技术采用了跨专业治疗方法来促进急性TBI的恢复。TBI管理在特殊人群中面临多重挑战,如儿科患者、老年人和士兵。个性化医疗、大数据分析和全球合作被强调为未来的研究方向。这项详细研究应提醒研究人员和临床医生,持续创新对于为TBI患者提供更好的护理途径至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c15e/12405072/461beee65b6e/40708_2025_271_Fig1_HTML.jpg

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