[通过聚合酶链反应-限制性片段长度多态性检测秘鲁女性人乳头瘤病毒的人口统计学特征]

[Demographic characteristics of human papillomavirus detected by PCR-RFLP in peruvian women].

作者信息

Sullcahuaman-Allende Yasser, Castro-Mujica María Del Carmen, Mejía Farro Roberto, Castaneda Carlos A, Castillo Miluska, Dolores-Cerna Ketty, Poquioma Ebert

机构信息

Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú

出版信息

Rev Peru Med Exp Salud Publica. 2015 Jul-Sep;32(3):509-14.

PMID:26580934

Abstract

In order to determine the sociodemographic characteristics of human papillomavirus (HPV) in patients referred to the National Institute of Neoplastic Diseases (INEN) between 2012-2014, the detection of HPV in cervical cells was performed by polymerase chain reaction (PCR). In 465 cervical samples, 151 (32.5%) cases were HPV positive. The most common genotypes were HPV-16 (23.8%) and HPV-6 (11.9%). The presence of HPV was higher in women aged 17-29 years (OR = 2.64, 95% CI 1.14 to 6.13) and single women (OR = 2.31, 95% CI 1.37 to 3.91). The presence of genotypes of high-risk HPV was higher in single women (OR = 2.19, 95% CI 1.04 to 4.62). In conclusion, young and single women had a higher frequency of HPV-positive cases. Therefore participation by these groups should be emphasized in screening programs with combined molecular and cytological methods in order to detect the risk of developing cervical cancer in a timely manner.

摘要

为了确定2012年至2014年间转诊至国家肿瘤疾病研究所（INEN）的患者中人类乳头瘤病毒（HPV）的社会人口学特征，采用聚合酶链反应（PCR）对宫颈细胞中的HPV进行检测。在465份宫颈样本中，151例（32.5%）HPV呈阳性。最常见的基因型是HPV-16（23.8%）和HPV-6（11.9%）。17至29岁女性（比值比=2.64，95%置信区间1.14至6.13）和单身女性（比值比=2.31，95%置信区间1.37至3.91）中HPV的感染率更高。单身女性中高危HPV基因型的感染率更高（比值比=2.19，95%置信区间1.04至4.62）。总之，年轻和单身女性HPV阳性病例的发生率更高。因此，在采用分子和细胞学联合方法的筛查项目中，应强调这些人群的参与，以便及时发现患宫颈癌的风险。