• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2015年的内分泌干扰物：表观遗传的跨代遗传。

Endocrine disruptors in 2015: Epigenetic transgenerational inheritance.

作者信息

Skinner Michael K

机构信息

Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington 99164-4236, USA.

出版信息

Nat Rev Endocrinol. 2016 Feb;12(2):68-70. doi: 10.1038/nrendo.2015.206. Epub 2015 Nov 20.

DOI:10.1038/nrendo.2015.206
PMID:26585656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5287152/
Abstract

Endocrine disruptors are critical environmental exposures that influence health and can promote epigenetic transgenerational inheritance of disease and abnormal physiology. Advances in 2015 included analyses of the effects of endocrine disruptors on human disease, further examples of endocrine disruptors promoting transgenerational behavioural effects, insights into effects of endocrine disruptors on epigenetic programming of primordial germ cells and the finding that endocrine disruptors can transgenerationally promote genetic mutations.

摘要

内分泌干扰物是影响健康的关键环境暴露因素，可促进疾病和异常生理的表观遗传跨代遗传。2015年的进展包括对内分泌干扰物对人类疾病影响的分析、内分泌干扰物促进跨代表型效应的更多实例、对内分泌干扰物对原始生殖细胞表观遗传编程影响的见解，以及内分泌干扰物可跨代促进基因突变的发现。

相似文献

1
Endocrine disruptors in 2015: Epigenetic transgenerational inheritance.2015年的内分泌干扰物：表观遗传的跨代遗传。
Nat Rev Endocrinol. 2016 Feb;12(2):68-70. doi: 10.1038/nrendo.2015.206. Epub 2015 Nov 20.
2
Exposure to endocrine disruptor induces transgenerational epigenetic deregulation of microRNAs in primordial germ cells.接触内分泌干扰物会诱导原始生殖细胞中微小RNA的跨代表观遗传失调。
PLoS One. 2015 Apr 21;10(4):e0124296. doi: 10.1371/journal.pone.0124296. eCollection 2015.
3
Genetic resistance to DEHP-induced transgenerational endocrine disruption.遗传抵抗 DEHP 诱导的跨代内分泌干扰。
PLoS One. 2019 Jun 10;14(6):e0208371. doi: 10.1371/journal.pone.0208371. eCollection 2019.
4
Tertiary Epimutations - A Novel Aspect of Epigenetic Transgenerational Inheritance Promoting Genome Instability.三级表观突变——促进基因组不稳定的表观遗传跨代遗传的一个新方面。
PLoS One. 2016 Dec 19;11(12):e0168038. doi: 10.1371/journal.pone.0168038. eCollection 2016.
5
Transgenerational epigenetic imprints on mate preference.跨代表观遗传印记对配偶偏好的影响。
Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5942-6. doi: 10.1073/pnas.0610410104. Epub 2007 Mar 26.
6
Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming.在哺乳动物生殖细胞系中，表观基因组重编程可纠正内分泌干扰物的有害影响。
Genome Biol. 2015 Mar 27;16(1):59. doi: 10.1186/s13059-015-0619-z.
7
Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation?内分泌干扰化学物质的多代和跨代效应：表观遗传调控改变起了什么作用？
Semin Cell Dev Biol. 2015 Jul;43:66-75. doi: 10.1016/j.semcdb.2015.05.008. Epub 2015 May 28.
8
Endocrine disruptors and epigenetic transgenerational disease etiology.内分泌干扰物与表观遗传跨代疾病病因学。
Pediatr Res. 2007 May;61(5 Pt 2):48R-50R. doi: 10.1203/pdr.0b013e3180457671.
9
Endocrine disrupters, microRNAs, and primordial germ cells: a dangerous cocktail.内分泌干扰物、microRNAs 和原始生殖细胞：危险的鸡尾酒。
Fertil Steril. 2016 Sep 15;106(4):871-9. doi: 10.1016/j.fertnstert.2016.07.1100. Epub 2016 Aug 11.
10
Transgenerational sperm DNA methylation epimutation developmental origins following ancestral vinclozolin exposure.祖代暴露于 vinclozolin 后发生的跨代精子 DNA 甲基化表观遗传突变与发育起源有关。
Epigenetics. 2019 Jul;14(7):721-739. doi: 10.1080/15592294.2019.1614417. Epub 2019 May 13.

引用本文的文献

1
Lemming and Vole Cycles: A New Intrinsic Model.旅鼠和田鼠种群数量周期：一种新的内在模型。
Ecol Evol. 2024 Oct 21;14(10):e70440. doi: 10.1002/ece3.70440. eCollection 2024 Oct.
2
Transgenerational epigenetic self-memory of dosage is associated with methylation and altered growth trajectories and neonatal hormones.代际表观遗传剂量自我记忆与甲基化和生长轨迹改变以及新生儿激素有关。
Epigenetics. 2024 Dec;19(1):2376948. doi: 10.1080/15592294.2024.2376948. Epub 2024 Jul 11.
3
Epigenetic signatures of social status in wild female spotted hyenas (Crocuta crocuta).野生雌性斑点鬣狗（Crocuta crocuta）社会地位的表观遗传特征。
Commun Biol. 2024 Mar 28;7(1):313. doi: 10.1038/s42003-024-05926-y.
4
Multiple generation distinct toxicant exposures induce epigenetic transgenerational inheritance of enhanced pathology and obesity.多代不同的毒物暴露会引发病理增强和肥胖的表观遗传跨代遗传。
Environ Epigenet. 2023 Dec 7;9(1):dvad006. doi: 10.1093/eep/dvad006. eCollection 2023.
5
Decoding the Influence of Obesity on Prostate Cancer and Its Transgenerational Impact.解析肥胖对前列腺癌的影响及其跨代效应。
Nutrients. 2023 Nov 21;15(23):4858. doi: 10.3390/nu15234858.
6
X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity.X盒结合蛋白1导致邻苯二甲酸二（2-乙基己基）酯诱导的未成熟大鼠睾丸毒性中细胞焦亡和线粒体自噬失衡。
Genes Dis. 2023 Mar 27;11(2):935-951. doi: 10.1016/j.gendis.2023.02.030. eCollection 2024 Mar.
7
Paternal developmental thyrotoxicosis disrupts neonatal leptin leading to increased adiposity and altered physiology of the melanocortin system.父源性发育性甲状腺毒症会破坏新生儿瘦素，导致脂肪过多，并改变黑素皮质素系统的生理机能。
Front Endocrinol (Lausanne). 2023 Jul 25;14:1210414. doi: 10.3389/fendo.2023.1210414. eCollection 2023.
8
A Genetics Study in the Foreskin of Boys with Hypospadias.一项关于尿道下裂男孩包皮的遗传学研究。
Mol Syndromol. 2023 Jun;14(3):185-190. doi: 10.1159/000527405. Epub 2023 Jan 16.
9
Endocrine-Disrupting Chemicals and Disease Endpoints.内分泌干扰化学物质与疾病终点
Int J Mol Sci. 2023 Mar 10;24(6):5342. doi: 10.3390/ijms24065342.
10
Nutriepigenomics in Environmental-Associated Oxidative Stress.环境相关氧化应激中的营养表观基因组学
Antioxidants (Basel). 2023 Mar 21;12(3):771. doi: 10.3390/antiox12030771.

本文引用的文献

1
Environmentally induced epigenetic transgenerational inheritance of sperm epimutations promote genetic mutations.环境诱导的精子表观突变的表观遗传跨代遗传促进基因突变。
Epigenetics. 2015;10(8):762-71. doi: 10.1080/15592294.2015.1062207.
2
Transgenerational Effects of Di-(2-Ethylhexyl) Phthalate (DEHP) on Stress Hormones and Behavior.邻苯二甲酸二（2-乙基己基）酯（DEHP）对应激激素和行为的跨代影响
Endocrinology. 2015 Sep;156(9):3077-83. doi: 10.1210/EN.2015-1326. Epub 2015 Jul 13.
3
A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development.一个独特的基因调控网络为发育重置人类生殖系表观基因组。
Cell. 2015 Jun 4;161(6):1453-67. doi: 10.1016/j.cell.2015.04.053.
4
Is Hypospadias Associated with Prenatal Exposure to Endocrine Disruptors? A French Collaborative Controlled Study of a Cohort of 300 Consecutive Children Without Genetic Defect.尿道下裂是否与内分泌干扰物的产前暴露有关？一项法国协作对照研究，对 300 例无遗传缺陷的连续儿童队列进行研究。
Eur Urol. 2015 Dec;68(6):1023-30. doi: 10.1016/j.eururo.2015.05.008. Epub 2015 May 23.
5
Exposure to endocrine disruptor induces transgenerational epigenetic deregulation of microRNAs in primordial germ cells.接触内分泌干扰物会诱导原始生殖细胞中微小RNA的跨代表观遗传失调。
PLoS One. 2015 Apr 21;10(4):e0124296. doi: 10.1371/journal.pone.0124296. eCollection 2015.
6
Epigenetic mechanisms underlying learning and the inheritance of learned behaviors.学习和习得行为遗传的表观遗传机制。
Trends Neurosci. 2015 Feb;38(2):96-107. doi: 10.1016/j.tins.2014.12.003. Epub 2014 Dec 24.
7
Endocrine disruptor induction of epigenetic transgenerational inheritance of disease.内分泌干扰物诱导疾病的表观遗传跨代遗传。
Mol Cell Endocrinol. 2014 Dec;398(1-2):4-12. doi: 10.1016/j.mce.2014.07.019. Epub 2014 Jul 31.
8
Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans.人类环境邻苯二甲酸酯暴露与生殖结局及其他健康终点的关系。
Environ Res. 2008 Oct;108(2):177-84. doi: 10.1016/j.envres.2008.08.007.
9
Epigenetic transgenerational actions of endocrine disruptors and male fertility.内分泌干扰物的表观遗传跨代作用与男性生育能力
Science. 2005 Jun 3;308(5727):1466-9. doi: 10.1126/science.1108190.