1 Division of Radiology, Mount Auburn Hospital, 330 Mount Auburn St, Cambridge, MA 02138.
2 Department of Gastroenterology, Mount Auburn Hospital, Cambridge, MA.
AJR Am J Roentgenol. 2015 Dec;205(6):1182-7. doi: 10.2214/AJR.15.14704.
Symptomatic lower esophageal (Schatzki) rings are one of the most common causes of dysphagia and esophageal food impaction. Although these rings are often diagnosed fluoroscopically, patients are typically referred for dilation procedures performed by a gastroenterologist. Because these procedures are invasive and carry risks, including esophageal perforation, an alternative treatment option is needed. Although recent research has shown the effectiveness of acid suppression medications used in addition to dilation procedures, our objective was to evaluate the effectiveness of treatment with acid suppression medication alone.
We retrospectively evaluated a cohort of nine patients who underwent barium esophagography at our institution to determine the ability to pass a 13-mm barium tablet and to identify a change in the lumen diameter of the lower esophageal rings after treatment with an oral proton pump inhibitor medication.
The median ring diameter was 10 mm (range, 8-15 mm) before treatment and 15 mm (range, 13-25 mm) after treatment, a statistically significant difference (p = 0.008). The median tablet passage score was 2 before treatment (with tablet passage paused briefly) and 1 after treatment (with the tablet passing through the esophagus easily without stopping), which was also a statistically significant difference (p = 0.02).
Significant improvements in both the ring lumen diameter and the ability to pass a tablet through the esophagus indicate that acid suppression medication is an effective alternative to the use of dilation procedures for the treatment of Schatzki rings.
有症状的食管下段(Schatzki)环是吞咽困难和食管食物嵌塞的最常见原因之一。尽管这些环通常在透视下诊断,但患者通常会被转介给胃肠病学家进行扩张术。由于这些程序具有侵入性且存在风险,包括食管穿孔,因此需要替代治疗选择。尽管最近的研究表明,除了扩张术之外,联合使用抑酸药物治疗的效果显著,但我们的目的是评估单独使用抑酸药物治疗的效果。
我们回顾性评估了在我们机构接受钡餐食管造影的九名患者的队列,以确定在使用口服质子泵抑制剂药物治疗后通过 13 毫米钡片剂的能力,并确定食管下段环的管腔直径变化。
治疗前的环直径中位数为 10 毫米(范围 8-15 毫米),治疗后为 15 毫米(范围 13-25 毫米),差异具有统计学意义(p = 0.008)。治疗前片剂通过评分中位数为 2(片剂通过时短暂停顿),治疗后为 1(片剂轻松通过食管而不停顿),差异也具有统计学意义(p = 0.02)。
食管下段环管腔直径和通过食管的片剂能力的显著改善表明,抑酸药物是治疗 Schatzki 环的扩张术的有效替代方法。