Burridge K, Fath K
Bioessays. 1989 Apr;10(4):104-8. doi: 10.1002/bies.950100403.
The sites of tightest adhesion that form between cells and substrate surfaces in tissue culture are termed focal contacts. The external faces of focal contacts include specific receptors, belonging to the integrin family of proteins, for fibronectin and vitronectin, two common components of extracellular matrices. On the internal (cytoplasmic) side of focal contacts, several proteins, including talin and vinculin, mediate interactions with the actin filament bundles of the cytoskeleton. The changes that occur in focal contacts as a result of viral transformation are discussed.
在组织培养中，细胞与底物表面之间形成的粘附最紧密的位点被称为粘着斑。粘着斑的外表面包括属于整合素蛋白家族的特定受体，用于结合纤连蛋白和玻连蛋白，这两种是细胞外基质的常见成分。在粘着斑的内部（细胞质）一侧，包括踝蛋白和纽蛋白在内的几种蛋白质介导与细胞骨架的肌动蛋白丝束的相互作用。本文讨论了病毒转化导致粘着斑发生的变化。
