Otey C A, Burridge K
Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599-7090.
Semin Cell Biol. 1990 Oct;1(5):391-9.
The extracellular matrices of different tissues contain components which affect the migration, morphology and differentiation of many types of cells. These forms of cell behavior often involve dramatic changes in cytoskeletal organization. Extracellular matrix components are recognized by specific cell surface receptors which span the membrane and interact with the actin cytoskeleton. In cultured cells, the matrix receptors are concentrated in sites of cell attachment called focal adhesions. Information that is conveyed from the extracellular matrix to the cytoskeleton may involve matrix components, cell surface receptors, as well as the proteins at the cytoplasmic face of the focal adhesion which link the receptors to the actin cytoskeleton.
不同组织的细胞外基质含有影响多种类型细胞迁移、形态和分化的成分。这些细胞行为形式通常涉及细胞骨架组织的显著变化。细胞外基质成分由跨膜的特定细胞表面受体识别，并与肌动蛋白细胞骨架相互作用。在培养细胞中，基质受体集中在称为粘着斑的细胞附着部位。从细胞外基质传递到细胞骨架的信息可能涉及基质成分、细胞表面受体，以及粘着斑细胞质面将受体与肌动蛋白细胞骨架相连的蛋白质。
