Wanat Karolyn A, Rosenbach Misha
Department of Dermatology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA; Department of Pathology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.
Department of Dermatology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Clin Chest Med. 2015 Dec;36(4):685-702. doi: 10.1016/j.ccm.2015.08.010. Epub 2015 Sep 26.
The skin is the second most common organ affected in sarcoidosis, which can affect patients of all ages and races, with African American women having the highest rates of sarcoidosis in the United States. The cutaneous manifestations are protean and can reflect involvement of sarcoidal granulomas within the lesion or represent reactive non-specific inflammation, as seen with erythema nodosum. Systemic work-up is necessary in any patient with cutaneous involvement of sarcoidal granulomas, and treatment depends on other organ involvement and severity of clinical disease. Skin-directed therapies are first line for mild disease, and immunomodulators or immunosuppressants may be necessary.
皮肤是结节病中第二常见受累的器官，结节病可影响所有年龄和种族的患者，在美国非裔美国女性的结节病发病率最高。皮肤表现多种多样，可反映病变内结节状肉芽肿的累及情况，或表现为反应性非特异性炎症，如结节性红斑所见。任何有皮肤结节状肉芽肿累及的患者都需要进行全面的系统检查，治疗取决于其他器官的累及情况和临床疾病的严重程度。针对轻度疾病，以皮肤为导向的治疗是一线治疗方法，可能需要使用免疫调节剂或免疫抑制剂。
