Selvaraj Sonia, Ssk Ambigai, Rangarajan Sudha, Dennis Joseph Leena, Swaminathan Adikrishnan
Dermatology Venereology Leprosy, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
General Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Cureus. 2025 May 31;17(5):e85135. doi: 10.7759/cureus.85135. eCollection 2025 May.
Micropapular sarcoidosis represents an uncommon variant of cutaneous sarcoidosis, typically presenting with a sudden onset, often resolving without residual scarring, and generally favorable prognosis. Its resemblance to other chronic papular dermatoses makes diagnosis challenging, especially in cases with subtle or localized cutaneous manifestations. We report a case of a 36-year-old female who presented with gradually progressive, asymptomatic skin-colored, and erythematous papules localized to the periorbital and perioral regions over six months. Systemic symptoms were absent, and routine blood investigations revealed anemia and elevated erythrocyte sedimentation rate (ESR). Skin biopsy revealed noncaseating epithelioid granulomas with lymphocytes suggestive of cutaneous sarcoidosis. The patient responded well to a combination of oral corticosteroids, hydroxychloroquine, and topical corticosteroids, with near-complete resolution of lesions and residual post-inflammatory hyperpigmentation over a period of three months. This case emphasizes the importance of considering micropapular sarcoidosis in the differential diagnosis of chronic facial papular eruptions and highlights the effectiveness of early appropriate treatment.
微丘疹型结节病是皮肤结节病的一种罕见变体,通常起病突然,常常消退后不留瘢痕,且一般预后良好。它与其他慢性丘疹性皮肤病相似,这使得诊断具有挑战性,尤其是在皮肤表现细微或局限的病例中。我们报告一例36岁女性患者,其在六个月内出现逐渐进展的、无症状的肤色及红斑丘疹,局限于眶周和口周区域。无全身症状,常规血液检查显示贫血和红细胞沉降率(ESR)升高。皮肤活检显示非干酪样上皮样肉芽肿伴淋巴细胞,提示皮肤结节病。患者对口服皮质类固醇、羟氯喹和外用皮质类固醇联合治疗反应良好,在三个月内皮损几乎完全消退,仅遗留炎症后色素沉着。该病例强调了在慢性面部丘疹性皮疹的鉴别诊断中考虑微丘疹型结节病的重要性,并突出了早期适当治疗的有效性。