Quality of Life Assessment in Sarcoidosis.

Quantifying health-related quality of life (HRQL) and specific patient symptoms has developed to include rigorous techniques to develop patient-reported outcome measures (PROs). PROs may assess objectively the impact of a therapeutic intervention in a clinical sarcoidosis trial, and may be useful in following HRQL. Item response theory may lead to the construction of PROs that allow for the development of short forms, the PRO to be focused on specific areas along the continuum of the trait being studied, and the development of computer-adaptive testing where HRQL can be assessed accurately using very few items.