Hoth Karin F, Simmering Jacob, Croghan Anna, Hamzeh Nabeel Y
Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA.
J Clin Med. 2022 Jun 22;11(13):3594. doi: 10.3390/jcm11133594.
Subjective cognitive difficulties are common among sarcoidosis patients; however, previous studies have not modeled the link between cognitive difficulties and health-related quality of life (HRQOL).
To determine whether cognitive difficulties are associated with HRQOL in sarcoidosis patients after adjusting for demographics, fatigue, and physical disease severity measures.
We performed a secondary analysis of the Genomic Research in Alpha-1 antitrypsin Deficiency and Sarcoidosis (GRADS) study data. We examined the association between self-reported cognitive difficulties (Cognitive Failures Questionnaire (CFQ)) and HRQOL (SF12v2 mental and physical component scores) while adjusting for the demographics, fatigue, and physical disease severity measures (i.e., organ involvement, forced vital capacity).
Approximately one-fourth of the patients with sarcoidosis endorsed cognitive difficulties. More frequent cognitive difficulties and more severe fatigue were significantly associated with worse mental HRQOL in the fully adjusted model, while older age was associated with better mental HRQOL. The association between cognitive difficulties and physical HRQOL was not significant in the final model. More severe fatigue, joint involvement, and reduced forced vital capacity (FVC) were associated with worse physical HRQOL, while higher income and higher education were associated with better physical HRQOL.
Perceived cognitive difficulties are associated with diminished HRQOL after adjusting for demographics, organ involvement, pulmonary function, and fatigue. The association between cognitive difficulties and reduced HRQOL primarily occurs through the impact on mental components of HRQOL.
主观认知困难在结节病患者中很常见；然而，以往的研究尚未建立认知困难与健康相关生活质量（HRQOL）之间的联系。
在调整人口统计学、疲劳和身体疾病严重程度指标后，确定结节病患者的认知困难是否与HRQOL相关。
我们对α-1抗胰蛋白酶缺乏症和结节病的基因组研究（GRADS）数据进行了二次分析。我们在调整人口统计学、疲劳和身体疾病严重程度指标（即器官受累情况、用力肺活量）的同时，研究了自我报告的认知困难（认知失误问卷（CFQ））与HRQOL（SF12v2心理和身体成分得分）之间的关联。
约四分之一的结节病患者认可存在认知困难。在完全调整模型中，更频繁的认知困难和更严重的疲劳与较差的心理HRQOL显著相关，而年龄较大与较好的心理HRQOL相关。在最终模型中，认知困难与身体HRQOL之间的关联不显著。更严重的疲劳、关节受累和用力肺活量（FVC）降低与较差的身体HRQOL相关，而较高的收入和较高的教育水平与较好的身体HRQOL相关。
在调整人口统计学、器官受累情况、肺功能和疲劳因素后，感知到的认知困难与HRQOL降低相关。认知困难与HRQOL降低之间的关联主要通过对HRQOL心理成分的影响而发生。
