Lai Jinsheng, Zhang Yemao, Liu Xingfa, Zhang Jiangong, Ruan Guoran, Chaugai Sandip, Chen Chen, Wang Dao Wen
Department of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
High Voltage Research Institute, China Electric Power Research Institute, Wuhan 430074, People's Republic of China.
Neurotoxicology. 2016 Jan;52:104-13. doi: 10.1016/j.neuro.2015.11.010. Epub 2015 Nov 22.
Recently, extremely low frequency electromagnetic fields (ELF-EMF) have received considerable attentions for their potential pathogenicity. In the present study, we explored the effects of ELF-EMF on behaviors of adult male rats. Sixty adult male rats were randomly divided into two groups, the sham exposure group and the 50Hz/100μT ELF-EMF exposure group. During the 24 weeks exposure, body weight, as well as food and water intake were recorded. Results showed that food and water intake and the body weight of the rats were not affected by the exposure. After 24 weeks exposure, open field test and elevated plus maze were conducted to evaluate the anxiety-like behavior, the tail suspension test and forced swim test were conducted to evaluate depression-like behavior and Morris water maze and fear conditioning tests were used to evaluate the cognitive and memory ability. Exposure to ELF-EMF did not induce any anxiety-like or depression-like behaviors compared with the sham exposure. Moreover, the cognitive and memory ability was not impaired by the ELF-EMF exposure. Furthermore, ELF-EMF exposure did not affect the morphology and histology of the brain. In conclusion, 24 weeks exposure to 50Hz/100μT ELF-EMF had no effect on the behaviors of the adult male rats.
最近，极低频电磁场（ELF-EMF）因其潜在的致病性而受到了广泛关注。在本研究中，我们探究了ELF-EMF对成年雄性大鼠行为的影响。将60只成年雄性大鼠随机分为两组，即假暴露组和50Hz/100μT ELF-EMF暴露组。在24周的暴露期间，记录大鼠的体重、食物和水的摄入量。结果显示，大鼠的食物和水摄入量以及体重不受暴露影响。暴露24周后，进行旷场试验和高架十字迷宫试验以评估焦虑样行为，进行悬尾试验和强迫游泳试验以评估抑郁样行为，并使用莫里斯水迷宫试验和恐惧条件试验来评估认知和记忆能力。与假暴露组相比，暴露于ELF-EMF并未诱发任何焦虑样或抑郁样行为。此外，ELF-EMF暴露并未损害认知和记忆能力。此外，ELF-EMF暴露并未影响大脑的形态和组织学。总之，暴露于50Hz/100μT ELF-EMF 24周对成年雄性大鼠的行为没有影响。
