从尖叶蓝花楹（紫葳科）中分离得到的一种新型双黄酮的细胞毒性活性及分子对接

Cytotoxic activity and molecular docking of a novel biflavonoid isolated from Jacaranda acutifolia (Bignoniaceae).

作者信息

Mostafa Nada M, Ashour Mohamed L, Eldahshan Omayma A, Singab Abdel Nasser B

机构信息

a Faculty of Pharmacy, Department of Pharmacognosy , Ain Shams University , Cairo , Egypt.

出版信息

Nat Prod Res. 2016 Sep;30(18):2093-100. doi: 10.1080/14786419.2015.1114938. Epub 2015 Nov 23.

DOI:10.1080/14786419.2015.1114938

PMID:26594904

Abstract

A novel biflavonoid [kaempferol (6→8″) apigenin] was isolated from the leaves of Jacaranda acutifolia. The structure was elucidated based on chemical evidence, 1D and 2D spectroscopic analyses as well as spectrometric techniques. The compound showed promising cytotoxic activity against breast cancer cell line MCF-7. The anticancer activity was explained via virtual docking of the isolated compound to the main sites in the human cyclin-dependent kinase2 (CDK2) crystal structure.

摘要

从尖叶蓝花楹的叶子中分离出一种新型双黄酮类化合物[山奈酚(6→8″)芹菜素]。基于化学证据、一维和二维光谱分析以及光谱技术对其结构进行了阐明。该化合物对乳腺癌细胞系MCF-7显示出有前景的细胞毒性活性。通过将分离出的化合物与人细胞周期蛋白依赖性激酶2(CDK2)晶体结构中的主要位点进行虚拟对接来解释其抗癌活性。