Shao Meng, Huang Xiao-Jun, Liu Jun-Shan, Han Wei-Li, Cai Hong-Bing, Tang Qing-Fa, Fan Qin
a School of Traditional Chinese Medicine , Southern Medical University , Guangzhou 510515 , China.
b Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , China.
Nat Prod Res. 2016 Jun;30(12):1417-22. doi: 10.1080/14786419.2015.1062379. Epub 2015 Aug 7.
One new chalcone-flavone biflavonoid, 3'-hydroxydaphnodorin A (1), together with 12 known biflavonoids (2-13), was isolated from the rhizome of Wikstroemia indica. Their structures were established on the basis of extensive spectroscopic methods. Eight isolated compounds 1-3, 6, 7, 9, 12 and 13 were evaluated for their cytotoxic activities against cancer-derived cell lines Hep3B, HepG2 and CNE2, and 1 was found to possess moderate cytotoxicity against HepG2 and CNE2 cell lines, with IC50 values of 65.5 ± 11.4 and 53.6 ± 10.1 μM, respectively.
从了哥王的根茎中分离出一种新的查尔酮-黄酮双黄酮类化合物3'-羟基南蛇藤素A（1）以及12种已知的双黄酮类化合物（2 - 13）。它们的结构通过广泛的光谱方法得以确定。对分离得到的8种化合物1 - 3、6、7、9、12和13进行了针对癌症来源细胞系Hep3B、HepG2和CNE2的细胞毒性活性评估，发现化合物1对HepG2和CNE2细胞系具有中等细胞毒性，IC50值分别为65.5±11.4和53.6±10.1μM。
