体外参与针对恶性疟原虫血液阶段的非特异性和抗体依赖性机制的效应细胞。
Effector cells involved in nonspecific and antibody-dependent mechanisms directed against Plasmodium falciparum blood stages in vitro.
作者信息
Lunel F, Druilhe P
机构信息
Faculté de Médecine Paris VI, France.
出版信息
Infect Immun. 1989 Jul;57(7):2043-9. doi: 10.1128/iai.57.7.2043-2049.1989.
Abstract
We have evaluated in in vitro conditions the possible cooperative effect of antimalarial antibodies with several human blood cell types. When used alone, immunoglobulin G from African adults who had reached a state of premunition against malaria was found to have no or very limited direct effect on invasion and multiplication of P. falciparum asexual blood stages. In contrast, these antibodies induced a marked specific inhibition of parasite growth in the presence of normal blood monocytes, and the inhibition did not appear to be strain dependent. No similar antibody-dependent cellular inhibitory effect was found using human blood polymorphonuclear leukocytes, lymphocytes, platelets, or adherent spleen cells. However, these cells could all exert in vitro some non-antibody-dependent inhibitory effect when present at high effector/target cell ratios.
摘要
我们在体外条件下评估了抗疟抗体与几种人类血细胞类型可能的协同作用。单独使用时，发现来自已达到疟疾带虫免疫状态的非洲成年人的免疫球蛋白G对恶性疟原虫无性血液阶段的侵入和增殖没有或只有非常有限的直接作用。相比之下，在正常血液单核细胞存在的情况下，这些抗体可诱导对寄生虫生长的显著特异性抑制，且这种抑制似乎不依赖于菌株。使用人类血液多形核白细胞、淋巴细胞、血小板或贴壁脾细胞未发现类似的抗体依赖性细胞抑制作用。然而，当以高效应细胞/靶细胞比例存在时，这些细胞都能在体外发挥一些非抗体依赖性抑制作用。
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