人类疟疾中的特异性抗体依赖性细胞毒性
Specific antibody-dependent cellular cytotoxicity in human malaria.
作者信息
Brown J, Smalley M E
出版信息
Clin Exp Immunol. 1980 Sep;41(3):423-9.
Abstract
A micromethod for the study of specific antibody-dependent cellular cytotoxicity (ADCC) in human malaria is described, using cultured, asexual Plasmodium falciparum parasites as viable target cells. Lymphocytes from children with acute malaria, uninfected immune adult Gambians and adult Gambians infected with P. falciparum were capable of killing P. falciparum in vitro in the presence of malaria antibody. A parasite growth-promoting factor, produced by lymphocytes in non-immune serum and at a lymphocyte--parasite ratio of 10:1, in immune serum, was found to produce three-fold increases in growth of P. falciparum. The mechanisms by which ADCC may occur are also discussed.
摘要
本文描述了一种用于研究人类疟疾中特异性抗体依赖性细胞毒性（ADCC）的微量方法，该方法使用培养的恶性疟原虫无性繁殖体作为活靶细胞。急性疟疾患儿、未感染的免疫成年冈比亚人以及感染恶性疟原虫的成年冈比亚人的淋巴细胞，在存在疟疾抗体的情况下能够在体外杀死恶性疟原虫。发现在非免疫血清中以及淋巴细胞与寄生虫比例为10:1时，淋巴细胞产生的一种寄生虫生长促进因子，在免疫血清中可使恶性疟原虫的生长增加三倍。文中还讨论了ADCC可能发生的机制。
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