Liu C C, Baylink D J
J Dent Res. 1977 Mar;56(3):304-11. doi: 10.1177/00220345770560031601.
In sham-operated and TPTX animals, F treatment did not affect final body weight, or serum Ca and P. In sham-treated rats, serum iPTH was not affected by F treatment. At the periosteum, F increased bone formation rate and bone and matrix apposition rates. At the endosteum, F treatment decreased forming surface, bone formation rate, bone and matrix apposition rates, and osteoid maturation rate; and increased endosteal resorbing surface and medullary area. The above-described F effects on bone were observed in TPTX as well as sham-treated animals. The effect of F treatment to stimulate periosteal matrix apposition was enchanced by TPTX. These results indicate that bone changes seen in animals treated with large amounts of F are not due to increased parathyroid activity.
在假手术和甲状腺全切除的动物中，氟处理不影响最终体重、血清钙和磷。在假处理的大鼠中，血清甲状旁腺激素不受氟处理的影响。在骨膜处，氟增加骨形成率以及骨和基质沉积率。在内骨膜处，氟处理降低形成表面、骨形成率、骨和基质沉积率以及类骨质成熟率；并增加内骨膜吸收表面和骨髓面积。上述氟对骨的影响在甲状腺全切除动物以及假处理动物中均有观察到。甲状腺全切除增强了氟处理刺激骨膜基质沉积的作用。这些结果表明，大量氟处理动物中出现的骨变化并非由于甲状旁腺活性增加所致。
