Schreurs Rick, Wiegerinck Rob F, Prinzen Frits W
Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
Card Electrophysiol Clin. 2015 Dec;7(4):599-608. doi: 10.1016/j.ccep.2015.08.012.
Cardiac resynchronization therapy (CRT) is an important therapy for heart failure patients with prolonged QRS duration. In patients with left bundle branch block the altered left ventricular electrical activation results in dyssynchronous, inefficient contraction of the left ventricle. CRT aims to reverse these changes and to improve cardiac function. This article explores the electrophysiologic and hemodynamic changes that occur during CRT in patient and animal studies. It also addresses how novel techniques, such as multipoint and endocardial pacing, can further improve the electromechanical response.
心脏再同步治疗（CRT）是治疗QRS波时限延长的心力衰竭患者的重要方法。在左束支传导阻滞患者中，左心室电激活改变导致左心室收缩不同步、效率低下。CRT旨在逆转这些变化并改善心脏功能。本文探讨了在患者和动物研究中CRT期间发生的电生理和血流动力学变化。它还讨论了诸如多点起搏和心内膜起搏等新技术如何能够进一步改善机电反应。
