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产金属β-内酰胺酶铜绿假单胞菌在肾移植重症监护病房的传播及其与环境的潜在关联

Transmission of metallo-β-lactamase-producing Pseudomonas aeruginosa in a nephrology-transplant intensive care unit with potential link to the environment.

作者信息

Ambrogi V, Cavalié L, Mantion B, Ghiglia M-J, Cointault O, Dubois D, Prère M-F, Levitzki N, Kamar N, Malavaud S

机构信息

Equipe Opérationnelle d'Hygiène Hospitalière, CHU Toulouse, Toulouse, France.

Biologie - bactériologie hygiène, CHU Toulouse, Toulouse, France; INSERM UMR1043, CNRS UMR5282, Université Toulouse III-INRA USC1360, France.

出版信息

J Hosp Infect. 2016 Jan;92(1):27-9. doi: 10.1016/j.jhin.2015.09.007. Epub 2015 Oct 9.

DOI:10.1016/j.jhin.2015.09.007
PMID:26597635
Abstract

Pseudomonas aeruginosa has been recovered in hospitals from many different sources including sinks and taps. Because P. aeruginosa is one of the main agents of nosocomial infections and increasingly resistant to antibiotics, environmental reservoirs in hospital settings are of great concern. We report here on a cluster of five cases of infection by P. aeruginosa expressing VIM carbapenemases (VIM-PA) in a nephrology intensive care unit. Our investigation pointed to transmission of VIM-PA via hands related to a contaminated tap. VIM-PA may be cross-transmitted to other patients if an environmental reservoir exists. Sinks and taps should be well designed and thoroughly cleaned and disinfected, and use of alcohol hand rub should be promoted.

摘要

铜绿假单胞菌已在医院的许多不同来源中被检出,包括水槽和水龙头。由于铜绿假单胞菌是医院感染的主要病原体之一,且对抗生素的耐药性日益增强,医院环境中的储存库备受关注。我们在此报告了在一个肾病重症监护病房发生的5例由产VIM碳青霉烯酶的铜绿假单胞菌(VIM-PA)引起的感染病例群。我们的调查表明,VIM-PA通过与受污染水龙头相关的手部进行传播。如果存在环境储存库,VIM-PA可能会交叉传播给其他患者。水槽和水龙头应设计良好,并进行彻底清洁和消毒,同时应推广使用酒精擦手液。

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